New article out now regarding the pharmacology of #psilocybin analogues including other compounds found in psilocybin-containing mushrooms, their active metabolites, and 4-acetoxy derivatives. pubs.acs.org/doi/10.1021/ac… #pharmacology #psychedelics #aeruginascin #baeocystin

SARs for #psilocybin, #baeocystin, #aeruginascin, & related analogs to produce effects in mice. New report on the receptor binding profiles, functional activities, and acute in vivo effects (HTR, body temp, locomotion).#psychedelics #pharmacology go.acs.org/2LO

Out now! Potential non-5-HT receptor targets of various #psychedelic tryptamines #Psilocybin-like effects and potency of 4-PrO-DMT in mice consistent with reports of its subjective effects 5-HT1A activity influenced 5-HT2A mediated HTR pubs.acs.org/doi/10.1021/ac… ACS Publications Bio & Med Chem Content

⏩️ Find the answers in this pre-proof on the comparative neuropharmacology of #U47700, #Ndesethylisotonitazene, #brorphine & more 🔀 In vitro + in vivo (rats) profiling ⏯️ doi.org/10.1016/j.drug… Always a pleasure to work with Dr Baumann and team! 🙌🌏 Designer Drug Research Unit Grant Glatfelter

Comparative #neuropharmacology of structurally distinct non-#fentanyl #opioids that are appearing on recreational drug markets worldwide Final version is live in @DrugAlcoholDep and you can download it right from this link! authors.elsevier.com/c/1hBPh1LiD3Dm…

Comparative neuropharmacology of structurally distinct non-fentanyl opioids that are appearing on recreational drug markets worldwide: doi.org/10.1016/j.drug… U-47700 HCL, isotonitazene, N-desethyl isotonitazene, and brorphine HCl were purchased from Cayman Chemical

Out now in @Psychopharm - Alkoxy chain length influenced the potency of #nitazene #opioids associated with human overdose. Christophe Stove Marthe Vandeputte Lei Shi link.springer.com/article/10.100…

The ED50 of the most potent #nitazene, #etonitazene (3 - 12 ug/kg), was ~10–17- & ~ 850–1,400-fold higher compared to #fentanyl & #morphine. In vitro and in vivo potencies were correlated across multiple assays and measures.

The result of yet another fantastic collaboration with the Designer Drug Research Unit (Michael Baumann) group now out in @Psychopharm: 👇 Grant Glatfelter et al., "Alkoxy chain length governs the potency of 2-benzylbenzimidazole 'nitazene' opioids associated with human overdose." 👏 #nitazenes