We have a #postoc #job offer in our MERCUR funded #DNA project on redox-active and catalytic #G4 #Quadruplex structures TU Dortmund. Experience in phosphoramidite chemistry and DNA synthesis? Please apply (English or German) through: jobs.tu-dortmund.de/job/view/995/w…

We have completed our first experiments on neutralization of Omicron by Pfizer BNT162b2 vaccination elicited immunity Manuscript available at sigallab.net and should be available on medRxiv in the coming days

Congratulations to the winners of the GDCh Division of Medicinal Chemistry's 2022 PhD Awards: Dr. Patrick Zanon Patrick Zanon, Dr. Johannes Morstein Johannes Morstein, and Dr. Verena Kunig! #FiMC2022 #medchem #pharma #drugdiscovery #euromedchemtalents #medchemtalents GDCh

We are very happy to announce that Kirujan Jeyakumar, from our lab, was awarded for his presentation at the “Frontiers in Medicinal Chemistry” conference! Congratulations!

Insight into Targeting Exon20 Insertion Mutations of the Epidermal Growth Factor Receptor with Wild Type-Sparing Inhibitors pubs.acs.org/doi/10.1021/ac…

This week Prof. Markus Seeliger from the Department of Pharmacological Sciences of Stony Brook University visited us and gave a great talk on ‘Kinetics of Kinase inhibitor binding and development of highly selective Cyclophilin Inhibitors’! #drugdiscovery

Our new preprint on covalent modification and inhibition of KRasG13C is just out. We developed nucleotide-based covalent inhibitors for KRasG13C, a clinically relevant oncogenic mutant of Ras that has not been successfully addressed in the past.

Beautiful science with our great friends from the Weizmann Institute! pubs.acs.org/doi/full/10.10…

Work from our Lab was featured in the first episode of Research Snapshots from @tudortmund! youtube.com/watch?v=073kqi…

Two of our PhD students had the honor to present their recent results at the FORTRESS meeting in Essen. Thanks again for the great organization and the opportunity to meet outstanding scientists, exchange exciting ideas and get in touch with new collaboration partners!

Ras mutations are found in almost 25 percent of cancer patients. New #ReviewedPreprint reports the targeting of a clinically relevant oncogenic Ras mutant with nucleotide-based covalent inhibitors. Drug Discovery Hub Dortmund sciety.org/articles/activ…

We have two open #Postdoc positions in #ProteinExpression and #Structuralbiology at the TU Dortmund ! More information here: rauh-lab.de/news-events-re…

We are pleased to announce that our paper entitled 'Targeting oncogenic KRasG13C with nucleotide-based covalent inhibitors' has been published in eLife - the journal! #KRAS #drugdiscovery doi.org/10.7554/eLife.… eLife - the journal

Our paper on FRAGTORY, published in J Med Chem, demonstrates the power of recursive pharmacophore-based fragment library design - paving the way for diverse and biologically meaningful screening libraries! Drug Discovery Hub Dortmund #DrugDiscovery #FBDD #Fragments pubs.acs.org/doi/10.1021/ac…

Exciting news! Our paper “Avapritinib-based SAR studies unveil a binding pocket in KIT and PDGFRA” is now published in Nature Portfolio ! #chemicalbiology #drugdiscovery doi.org/10.1038/s41467…

A new perspective on Akt Inhibitor Advancements: From Capivasertib Approval to Covalent-Allosteric Promises | Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/ac…

Taking it to the next level - Targeting KRAS Diversity: Covalent Modulation of G12X and Beyond in Cancer Therapy | Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/ac…

Big News: National network for the development of cancer drugs launched - the Deutsche Krebshilfe foundation is funding the national research network "TACTIC" with 11.8 million euros over five years! Read more: tu-dortmund.de/detail/nationa…

Promising substance against rare cancer licensed out! Full article here: tu-dortmund.de/detail/vielver…

Fighting drug-resistant GIST!🚀 We developed innovative covalent KIT/PDGFRA inhibitors using structure-based design. Check out our latest J Med Chem publication! doi.org/10.1021/acs.jm… #CancerResearch #DrugDiscovery