New #Research finds that C5a/C5aR1 axis activation primarily in interstitial cells contributes to the development of renal #fibrosis. 📝ow.ly/4kVK50JzJPG By: Didier Portilla, et al. #AJPRenal #Pericytes #RNASequencing UVA School of Medicine Daniel Chauss

5 websites to analyze GEO RNAseq data without a single line of code:👇🧵

Amazing week for #DeepLearning in #spatial #singlecell biology, with 2🔥new Graph Neural Networks methods! 1.STELLAR🇺🇸 Jure Leskovec: a cell type annotation & discovery atlas-type framework 2.NCEM🇪🇺 Fabian Theis: an approach to infer cellular communication patterns Deep dive below🧵

The Laboratory of Genomic Immunology and Henao-Mejia laboratories present their latest preprint titled "A multi-enhancer hub at the Ets1 locus controls T cell differentiation and allergic inflammation through 3D genome topology" biorxiv.org/content/10.110…

Single-cell or spatial? Our new technology - Slide-tags - allows both in the same experiment, enabling true single-cell multi-modal spatial genomics ➡️ doi.org/10.1101/2023.0…

Now online! C5a-licensed phagocytes drive sterilizing immunity during systemic fungal infection dlvr.it/SpRj1k

A new #NIAID study helps explain why drugs that suppress C5, a protein in the complement system, put people at risk of deadly #fungal infections. These findings show C5 plays a key role in antifungal immunity. Read more in @cellpressnews: doi.org/10.1016/j.cell… #immunology

Kudos to Jigar V Desai and many thanks to Behdad (Ben) Afzali Kemper Complement Lab Jean Lim Tilo Freiwald Daniel Chauss Dhaneshwar Kumar Melissa Johnson It's really Brendan! Luciana Negro Lakmali M Silva Marissa Zarakas Majid Kazemian and others (Niki, Mihai, Vinod, Heather, Jorg, John, Barb, Vas,Julie) not on Twitter!

#ICYMI: A study from researchers across NIH shows drugs suppressing complement C5 increase the risk of serious fungal infections, demonstrating the key role of locally-produced C5 in providing antifungal immunity. doi.org/10.1016/j.cell…

Single-cell transcriptomics of dynamic cell behaviour in rodent airways. elifesciences.org/articles/76645…

New microcircuit in the fruit fly visual system allowing a single signal type to be used for multiple purposes: another layer to understanding neuronal networks & the visual process! Amalia Braun @mmerier089 Max Planck Society MPI for Biological Intelligence Current Biology: bit.ly/3MM2OhO

Delighted to see our article on #TFs in #Tregs published in Nature Rev Immunol: nature.com/articles/s4157… Great collaborative effort from Jorge Luis Trujillo-Ochoa PhD. and Majid Kazemian on this one.

Looking for an updated review on the role of various transcription factors in #tregs ? Look no further than this brilliant review in NRI by my colleagues Jorge Luis Trujillo-Ochoa PhD. Majid Kazemian and Behdad (Ben) Afzali.

This relates to a huge effort by Ewy at NCATS showing that pre-existing #autoimmunity is associated with more severe #Covid_19. We only played a minor supporting role in this great study, which can be found here: academic.oup.com/cid/advance-ar…

In case you missed it, happy to share our awesome collaboration in Nature Immunology with Vanja Lazarevic on TF EGR2 in Th17 cells in the CNS!

For all the 5'UTR fans out there, this paper is for you. biorxiv.org/content/10.110…

Thrilled to announce our new paper in Nature Communications: "Benchmark and PET" 🎉! A fantastic collaboration with Majid Kazemian, Luopin, Purdue Biochemistry, & NIDDK. Science is a team sport! #CancerResearch #TeamScience #NIH #Bioinformatics Read more: nature.com/articles/s4146…

Ever wondered about the performance of tools like GSEA, EnrichR, or ORA in your research? So did we! Our latest study puts them to the test with a bespoke Benchmark. See how they measure up: nature.com/articles/s4146… #Bioinformatics #CancerResearch #Genomics