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Nice. Much better evaluation of DNA LMs on actually important tasks specifically focused on 3'-UTR. Motif discovery, variant scoring and MPRA activity prediction, mRNA half life prediction. 1/

‘RNA writing’ is latest tech to emerge in race to edit large blocks of genetic material. My story for Endpoints News on the method that hijacks RNA splicing to replace swathes of mRNA. Scientists say it's like the RNA version of prime editing or DNA writing. 🧵 endpts.com/rna-writing-is…

We developed an imaging-free spatial genomics technology where DNA barcodes diffuse to connect locally. Using UMAP, we reconstructed the physical locations of these barcodes, transforming spatial transcriptomics into purely molecular biology. biorxiv.org/content/10.110…

Our story on RNA-templated gene synthesis in antiviral immunity is out today in Science Magazine! We discovered a cryptic gene, neo, that is created de novo by infected cells in a remarkable feat of molecular gymnastics🤸 science.org/doi/10.1126/sc…

Today out in bioRxiv we present SCOPE. An optics-free, self-registering array of DNA encoded beads for spatial genomics. This was work led by the intrepid duo of Hanna Liao and Sanjay Kottapalli, with Jay Shendure's lab. biorxiv.org/content/10.110…

Thrilled, and also in a bit of disbelief, to see our paper featured on the cover of Science Magazine! "Finding Neo" wasn't easy, but we just kept swimming (read: stared at a sequence of DNA) until the Eureka moment hit.

Honored to be featured by the RNA Society this week! Huge thanks to Dawn Chen and AnyaS5150 for their fantastic write-up.

It was so cool to learn about your research!

Amazing work from my labmate, check it out!

Excited to share our lab's first preprint: we used spatial transcriptomics to dissect how aging disrupts the cycling ovary! 🧵 This was an incredible team effort w/ Jennifer Garrison Tammy Lan David Fischer AlisonKochersberger Ruth Raichur Sophia Szady

Today in nature we share our back-to-back stories with Ning Zheng revealing chemical-genetic convergence between a molecular glue & E3 ligase cancer mutations. 1/6

Very happy! Thank you to Weintraub Graduate Student Award, my lab Fei Chen Lab, all my mentors, collaborators, family and friends for your support!

Thrilled to share our latest work in which we built a tool to assay RNA content of various subcellular compartments within native cellular and tissue context! Green Center for Reproductive Biology Sciences UT Southwestern Medical Center nature.com/articles/s4146…

The peer-reviewed version of expansion in situ genome sequencing is now out in Science! The news is bittersweet – when we first revealed this last September, I never guessed it would be my final paper in academia, but a lot has changed. A few parting thoughts: