The time of day that we eat has significant impact on body weight and metabolic health but what determines those mealtimes? In a new study Nature Neuroscience, we monitored daily oscillations in the activity of key hypothalamic hunger neurons expressing AgRP. ++ nature.com/articles/s4159…

Surprisingly, long term variations in AgRP neuron activity were not fully consistent with their assumed role as an energy homeostat -activated by hunger and silenced by feeding-. Instead, chronic AgRP neuron activity oscillated in parallel with past circadian feeding experience++

The EPLS programme at Cambridge, which welcomes undergraduates from under-represented backgrounds a paid research experience over the summer, is now accepting applications! Please RT if this might be of interest to someone in your network!

I believe in Spinoza's God, Who reveals Himself in the lawful harmony of the world, not in a God Who concerns Himself with the fate and the doings of mankind. -- Albert Einstein (1879-1955), as mentioned in Geometrie and Erfahrung (1921)

Fiona Doetsch's lab strikes again: in pregnancy, subpopulations of NSCs in SVZ give rise to specific OB neurons critical for pup recognition and maternal care. science.org/doi/10.1126/sc…

Grigori Perelman, mathematician who proved the Poincaré Conjecture and who refused to accept a Fields Medal and the $1,000,000 Clay Prize, spotted at a traffic signal.

Almost all internet traffic is transmitted via submarine cables, which have a total length of around 1.3 million kilometers, or about three times the distance from the Earth to the Moon. 📽: Tyler Morgan-Wall

Anti-obesity compounds upregulate adult neurogenesis. Jorgensen et al. is online. I am glad to see it published. Have a merry Christmas and a happy new year. embopress.org/doi/full/10.10… Sara Jorgensen adult neurogenesis

Post-exercise protein loading seems to have no downside and one can load much more than the conventional wisdom. Cell Reports Medicine cell.com/cell-reports-m…

New! Online now: Exercise induces tissue-specific adaptations to enhance cardiometabolic health dlvr.it/T1GRS2

New! Online now: DMHPpp1r17 neurons regulate aging and lifespan in mice through hypothalamic-adipose inter-tissue communication dlvr.it/T1HxfR

"and then the journal asks the reviewers if they have any conflicts of interest!"

An integrated single‐cell RNA‐seq atlas of the mouse hypothalamic paraventricular nucleus links transcriptomic and functional types - Berkhout - 2024 - Journal of Neuroendocrinology - Wiley Online Library onlinelibrary.wiley.com/doi/full/10.11…

The strange, variable reference frames you get in a rough sea [📹 maritime_nation_]

It is a pleasure to host Sergio Gascon of the Cajal Institute in Cardiff. A great talk about epigenetics and neurogenesis. Work hard, play hard.

Sara and May helping to organise the 2024 Cardiff Science Festival Sara Jorgensen

This is remarkable doi.org/10.1038/s41586…

Starship vs Saturn V

Interesting interactions with colleagues and PhD students at a Great Western 4 Medical Research Council DTP meeting in Exeter, Devon.

New! Online now: Astrocytic LRP1 enables mitochondria transfer to neurons and mitigates brain ischemic stroke by suppressing ARF1 lactylation dlvr.it/T8XsKC