We recognized our reanalyses would spark ... discussion

Most points being 'discussed' online today were considered in our Letter.

In our key analysis, the diet effect is not significant taking into account the huge carry-over (2000 kcal/d)

Open access
👉sciencedirect.com/science/articl…

'Carry-Over' Effects in Cross-Over Trials

Final version of our paper out, April issue American Society for Nutrition Journals

👉Low-carb diet first made low-fat look BETTER
👉Low-fat diet first made low-carb look WORSE

Letters to Editor and a correction also online

Open access sciencedirect.com/science/articl…

Does inherent tastiness or 'hedonic' responses to food drive intake?

Or do metabolic effects of food determine how rewarding it is?

Classic study from M Friedman's lab suggests the latter.

Rats adapted to high fat diet absorb more fat and prefer it more journals.physiology.org/doi/abs/10.115…

How can doctors talk with patients about obesity?

6th episode in the Medscape series 'Treating Obesity: Confronting the New Normal'

Wise advise from Ania M. Jastreboff, MD, PhD and Chika V. Anekwe, MD MPH

Free to view (5 min): medscape.com/mtv/obesity-s0…

In mice, low-carb/high fat diet prevented:
👉weight gain
👉dyslipidemia
👉fatty liver

'Even though their caloric intake was comparable to that of' high sugar/high fat mice and greater than standard fed mice.

Authors cite carb-insulin model as support
frontiersin.org/articles/10.33…

Prevention of cardiovascular disease in T1 diabetes

Article considers ≥15 drug classes for lipids, BP, obesity, ins res, thrombosis. Clearly these play a major role in progress.

But ... number of times any specific diet mentioned?

👉Exactly ZERO

NEJM
nejm.org/doi/full/10.10…

Keto for mental health problems?

Promising pilot data from Shebani Sethi, MD and others

High impact philanthropy from #BaszuckiFoundation Jan Ellison Baszucki

Time for the definitive trial(s)!
washingtonpost.com/wellness/2024/…

'She was married off to a sugar cane laborer in western India at about 14 — 'too young ... to have any idea what marriage was.' Debt to her employer keeps her in the fields.'

Like coal miners in US a century ago ('You load 16 tons, what do you get? ...')
nytimes.com/2024/03/24/wor…

Delighted to discuss nationwide obesity prevention with Prime Minister Aksel Vilhelmson Johannesen of #FaroeIslands The Government of the Faroe Islands 🇫🇴

👉What can be accomplished when all segments of society join together to raise a healthy generation of children?

Early Carb-Insulin Model? Reprinted @JAMA from 1924

'Obviously—and experience confirms this—cereals and chemically similar foods must be eaten frequently and liberally to equal the “staying” qualities of...[protein and fat] so far as satiety is concerned'
jamanetwork.com/journals/jama/…

'Despite use of advanced diabetes technologies, a high proportion of people with type 1 diabetes do not achieve glycemic targets ... suggesting an ongoing need for improved treatment'

👉Maybe a diet lowering the macronutrient that raises glucose the most?
diabetesjournals.org/care/article/d…

With the Open Access glitch now corrected, the full text of our Reply letter American Society for Nutrition Journals is freely available.

Judge for yourself how well we addressed the criticisms of our Perspective paper at this link 👇👇👇
jn.nutrition.org/article/S0022-…

Our Reply Letter to Sciarrillo et al. on the low-carb versus low-fat diet trial Nature Medicine is online.

We respectfully disagree with most criticisms and look forward to a debate on the merits in the pages of scientific journals.

American Society for Nutrition Journals
#JNutr
jn.nutrition.org/article/S0022-…

Low-carb diets improve many metabolic syndrome risk factors

What about LDL-chol? Turns out weight is a key factor

LDLc ⬆️ in those with low BMI
LDLc ⬇️ in those with high BMI

So ... no special concern, it seems, for LDLc on low-carb for obesity/diabetes
ajcn.nutrition.org/article/S0002-…

An influential feeding study in Nature Medicine reported advantages of a low-fat vs low-carb diet for weight control.

Our reanalysis in American Society for Nutrition Journals reaches a different conclusion.

Implications for the NIH Precision Nutrition trials

Open access here: sciencedirect.com/science/articl…

Another example of obesity that can develop without increased food intake (hyperphagia occurs later)

This is more the rule than exception in animal models

And yet, the possibility that “overeating” doesn’t “cause” obesity is still considered preposterous
onlinelibrary.wiley.com/doi/10.1002/ob…

Updated summary of the #CarbInsulinModel

My 40 min talk at the The BMJ Swiss Re conference in Zurich
youtube.com/watch?v=8AphN1…

Obesity Paradigm Clash! Which comes first, overeating or increasing body fatness? New Challenges in Nutrition paper by Ludwig et al. compares the Energy Balance vs Carbohydrate-Insulin Models of obesity Springer Nature #CarbInsulinModel Dr. David Ludwig nature.com/articles/s4143…

Final version of our article on the new W.H.O. low-fat guidelines now available.

Full text access for 50 days through this link:
authors.elsevier.com/a/1hvEmgSEMrZG

SNAP (Food Stamps) reform is needed to address childhood obesity and hunger.

👉Empty calories don't fill empty bellies.

But low income people already struggle financially. SNAP reform should be link to initiatives to make healthful food accessible to all
washingtonpost.com/opinions/2023/…