Fantastic summary on the state of artificial cells

NEW PRE-PRINT: a decade after the RBS Calculator, read about our new Promoter Calculator, a biophysical model that predicts site-specific transcription initiation rates for *any* sigma70 promoter sequence. Work by Travis LaFleur and Ayaan Hossain biorxiv.org/content/10.110… /1

Research in Nature reports colloidal cell-like structures that can capture and release payloads from the external environment. go.nature.com/3l27cv6

Directed evolution of a periplasmic bacterial bile salt sensor enabled by the membrane spanning two-hybrid-like EMeRALD platform. Very nice work 👏

Can cells be engineered to infiltrate a tumor and blow it up from the inside? Yes, when they express #gasvesicles as seeds for ultrasound-triggered bubble cavitation! Congrats to star postdoc Avinoam Bar-Zion and team on this publication! nature.com/articles/s4156…

Congratulations to Scripps Research’s Ardem Patapoutian, who has been awarded the 2021 #NobelPrize for Physiology or Medicine. Patapoutian wins the award jointly with David Julius, for the discovery of receptors that sense temperature and touch scripps.edu/news-and-event… Ardem Patapoutian

Happy to share our new review in Chem!

Chemical and genetic screens in human cells using digitizer circuits go.nature.com/3GwMJs9

A naturally inspired antibiotic to target multidrug-resistant pathogens nature.com/articles/s4158…

Protein nanowires with tunable functionality and programmable self-assembly using sequence-controlled synthesis doi.org/10.1038/s41467…

Thrilled to announce a new piece of my PhD work - out today Nature Biotechnology! We developed a genetically-encoded encapsulation system to deliver therapeutic bacteria to tumors in mice go.nature.com/3tju12D Some highlights 🧵(1/9)

Alyssa, a 13-year old T-cell leukemia (ALL) patient in the UK, was the first person to receive a base editing therapeutic—T cells with three base edits—and the first patient reported to benefit from base editing: complete remission, 6 months later. 1/3 bbc.com/news/health-63…

Congratulations to Jeffery W. Kelly, 2023 Wolf Prize laureate in Chemistry! Scripps Research

Excited to share our research in Nature Chemical Biology ! We developed a bacterial orthogonal DNA replication system (BacORep) and equiped it with an engineered error-prone orthogonal DNA polymerase. OrthoRep, you just got a new friend :) 👉 nature.com/articles/s4158…

A titan of business and keen observer of the world around him, Charlie Munger helped build an American institution, and through his wisdom and insights, inspired a generation of leaders. He will be sorely missed. Rest in peace Charlie.

Congrats to Christian Diercks and other members of the Schultz lab on a new error-prone orthogonal replication system in E. coli! biorxiv.org/content/10.110…

Excited to share a new paper where we developed a live vaccine of Pseudomonas, conditionally dependent on an UAA. Congrats to Mike and the rest of the team! rdcu.be/dR9Ae

My lab at Calibr-Skaggs/Scripps Research is hiring a Biophysicist, the candidate will characterize molecular interactions between Proteins and DEL screening SM/Peptide hits using SPR. All with experience using SPR are welcome to apply! Postdoctoral Associate, Biophysics | Calibr

Happy to share the publication of our latest manuscript in Science! With Peter Schultz's lab and my team at Scripps Research we developed T7-ORACLE – an orthogonal replication system for continuous hypermutation and accelerated evolution in E. coli. science.org/doi/10.1126/sc…

Happy to see this new T7 replicon based orthogonal replication system in E. coli. Congrats to the Diercks and Schultz lab teams at Scripps Research! science.org/doi/10.1126/sc…