DeepMind open-sources AlphaFold 2 for protein structure predictions wp.me/p8wLEc-blZO by Kyle Wiggers

The Aravind lab is seeking a new postdoc: We would like someone with computation/bioinformatics background who is excited by the molecular details of biochemistry/biology to work on projects relating to protein evolution/discovering novel biochemistry/biological conflict systems

I don't know the Aravind group personally but my goodness have a couple of their papers really blown my mind and changed how I think about things (e.g. jumbophages and cyclic nucleotides).

Joe Bondy-Denomy Same here. Mougous lab and alum used to refer to their 2012 Biology Direct (Zhang et al) paper as the bible

Profiles from our work on nucleotide/NAD+-dependent and other immunity systems are now in Pfam: xfam.wordpress.com/2021/11/19/pfa… We had also reported the Crinkler Header domains involved in trafficking, one of which is a Ubl, in this work academic.oup.com/nar/article/44….

Glad to share that our recent discovery of a new globin family is published in CSBJ today. Yes, a new family of the famous globins! doi.org/10.1016/j.csbj…

Another recent work where we identified the potential toxins behinds Huanglongbing and Zebra chip: Comparative Phylogenomic Analysis Reveals Evolutionary Genomic Changes and Novel Toxin Families in Endophytic Liberibacter Pathogens | Microbiology Spectrum journals.asm.org/doi/10.1128/Sp…

Nature does open access

Look who's on the cover of Developmental Cell:the humble soil bacterium #Bacillus subtilis,in the act of sporulating,depicted using marbles and wooden blocks! Our paper tackles a ~50 yr old mystery of how the cell coordinates assembly of 2 supramolecular structures:sciencedirect.com/science/articl…

Machine learning can help read the language of life: blog.google/technology/ai/… Discussing our work in Nature Biotechnology, our interactive preprint, and why Google is involved.

Apply now to join our team!

Meta just dropped 600+ million protein structure predictions, made using a large language model. My latest for nature nature.com/articles/d4158… 1/3

I can't wait for the 2024 symposium on the "beyond CRISPR" immune system of bacteria, which will take place in Boston on April 16-18, 2024. Save the date!

Excited to share a recent collaborative work on anti-phage systems with Dr. Kevin D. Corbett at UCSD.

To be out soon: nucleotides at receiving end of counter-invader conflicts.

Excited to share our latest research with the Yap lab @Ribo1214 at Northwestern. We predict antibiotic resistance phenotypes by analyzing non-coding regulatory regions of erythromycin resistance RNA methyltransferase (erm) genes. read more in mSystems journals.asm.org/doi/10.1128/ms…

Wolbachia-mediated Cytoplasmic Incompatibility, transposons and other entanglements Our new collaborative work with ZhangLab_SLU lab is out. It investigates the fascinating phenomenon of the genomic basis of Cytoplasmic Incompatibility (CI) and its ultimate origins. This