🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

statnews.com/2025/05/06/how…

Excited that our work revealing the structure and function of the monster stress response silencing factor, the E3 ligase SIFI, is now out! Congratulations to the most amazing team of Zhi Yang, Diane Haakonsen, Michael Heider and Sam Witus! nature.com/articles/s4158…

From ⁦Novartis Science⁩: Therapeutic potential of allosteric HECT E3 ligase inhibition: Cell cell.com/cell/fulltext/…

Awesome to be back in Kendall sq again on such a beautiful day! Looking forward to the Chromatin Summit ⁦Foghorn Therapeutics⁩ tomorrow!

Congratulations to #MolecularTherapeutics faculty and Molecular Therapeutics Initiative member James Olzmann for receiving the Beatriz Manz award for 'transformational teaching and community service'. Glad to have you as a friend and colleague UC Berkeley , James!

Congratulations to MCB's Gloria Brar, Meng-meng Fu & Michael Rapé who received our 2025 MCB Outstanding Faculty Awards! 👏 🎉 Meng-meng Fu Rapé Lab mcb.berkeley.edu/news-and-event…

Our 2025 lab photo!

Congrats to chem bio grad students Ellie King, Lauren Orr, and Vienna Thomas on graduating with their PhD's!

Online today in nature - our latest study led by superstar postdoc Gilles Rademaker detailing the role of PSCK9 in driving sterol dependent metastatic organ choice in pancreatic cancer nature.com/articles/s4158… full text available here 👉 rdcu.be/em0VG and thread 👇

Happy to share our review on the exciting frontier of covalent chemistry aimed at non-cysteine residues — expanding the toolbox for ligand discovery and chemical biology. Congrats to Gibae Kim from my group! pubs.acs.org/doi/10.1021/ac… Covalent Modifiers UT Austin Chemistry UT Austin

I discuss the urgent crisis from the loss of federal support of science in the US and recent clinical gene editing breakthroughs with Walter Isaacson & Christiane Amanpour on Amanpour and Company, airing on PBS tonight at 11 pm ET, and on CNN International earlier today. Pls share! youtube.com/watch?v=8YhJM6…

Linker-free PROTACs efficiently induce the degradation of oncoproteins. nature.com/articles/s4146… Can someone explain this concept to me? I don't really understand the idea.🤔

Biotech Wisdom Of The Crowds: Competition And Capitalism In a sector defined by science, R&D, and risk capital, crowding isn’t necessarily a bug – it’s more of a feature. Winners will emerge from the crowd and bring differentiated drugs fwd to patients lifescivc.com/2025/05/biotec…

Cereblon (and its buddy, the cyclic imide) is Once Again in the spotlight! Excited to share the lab's latest pub, highlighting the effects of cyclic imide stereoisomers on CRBN activity! 🥳✨ Congrats to Yuka, Saki, and all the authors 🫶 pubs.rsc.org/en/content/art…

Thrilled this paper is out! We solved the first cocrystal structure of FSP1 with an inhibitor (FSEN1), providing mechanistic insight & a foundation for medchem. Led by amalia megarioti & Sitao Zhang. A terrific collaboration with Da Jia. Brief Tweetorial! 1/9 pnas.org/doi/10.1073/pn…

Excited to announce a new collaboration between the Molecular Therapeutics Initiative (MTI) and Amgen Inc.! This partnership includes funding for cutting-edge research & an internship program for grad students to train in drug discovery & development at Amgen. #MTI #Amgen

Happy to present our latest paper with Ryan Potts & Amgen 🧪🔬🧬 in J. Am. Chem. Soc. by co-first authors Charlotte Zammit & Cory Nadel on the discovery of a direct-acting covalent destabilizing degrader of AR and the undruggable truncation variant of AR, AR-V7, in androgen-independent prostate

Awesome being back in Boston for #ChemBiointhePub ahead of the Bioorganic Chemistry GRC!

Cool follow-up story from Cravatt lab on covalent targeting of NONO: Structural and mechanistic analysis of covalent ligands targeting the RNA-binding protein NONO | bioRxiv biorxiv.org/content/10.110…

Check out our lab's newest pub, live in ACS ChemBio! We report interesting CRBN-independent activities of N-alkylated lenalidomide derivatives, or "capped imides." Congrats to Farah and all of the authors! 🥳💐 pubs.acs.org/doi/10.1021/ac…