Today The Association of Ambulance Chief Executives has published a position paper setting out a future vision for NHS ambulance commissioning. Find out more and read the paper here: aace.org.uk/news/aace-publ…

When should you take your blood pressure medication? A new randomized trial shows no difference bedtime vs morning JAMA jamanetwork.com/journals/jama/…

A message for Wes Streeting The push for GP access has unintended downsides. Increasing appointments delays processing of admin - like access to referrals & prescriptions. Fatigue from too many patient interactions (bearing in mind we mainly see the most complex now) risks

Just one hour of indoor aerobic exercise can boost circulating levels of active vitamin D by 35%. Vitamin D is stored in the body's fat tissue. In obesity, large fat stores can sequester vitamin D, leading to lower serum levels of the major circulating form, 25(OH)D, despite

#CONFIDENCE 1⃣ + 1⃣ = 2⃣ Remarkably, kidney protection with combination therapy mathematically identical to what would be expected based on each monotherapy Finerenone (0.68) * Empagliflozin (0.71) Combination (Expected if Fully Additive): 0.48 Combination (Observed): 0.48

👉Aspirin in primary prevention? Maybe not for everyone. But definitely worth reconsidering for those with elevated Lp(a). This compelling article in The American Journal of Medicine challenges the current dogma: Lipoprotein(a) may redefine aspirin’s role in cardiovascular

📉 Who responds best to tirzepatide? Post hoc SURPASS-4 analysis ✅ Glycaemic control sustained in 75–84% 🔑 Predictors: higher dose, shorter T2DM duration, better β-cell function, metformin use, no albuminuria ✅ ≥10% weight loss sustained in 80% diabetesjournals.org/diabetes/artic…

Levemir insulin is to be discontinued, with an anticipated supply end date of December 2026. In response to this, ABCD and PCDO Society have published joint guidance to support clinicians in selecting and prescribing alternative insulins. 👉 eu1.hubs.ly/H0mmwQ80

🚨BREAKING: FDA grants accelerated approval to Wegovy (semaglutide 2.4 mg injection) for treating adults with non‑cirrhotic metabolic dysfunction‑associated steatohepatitis (MASH) with moderate to advanced liver fibrosis - - - A Fourth Indication for Wegovy Wegovy’s FDA-approved

Thread: Major Changes in 2025 ACC/AHA #Hypertension Guidelines vs 2017 1⃣ BP Classification No change. HTN still defined as ≥130/80 mmHg. Normal <120/80, Elevated 120–129/<80, Stage 1: 130–139/80–89, Stage 2: ≥140/90

Congress did its homework on Nigel Farage:

SGLT2 inhibitor therapy and lower incidence of iron deficiency anaemia in patients with type 2 diabetes: A retrospective cohort study from Germany SGLT2i therapy was associated with a lower incidence of IDA in T2DM patients compared to DPP-4i therapy. These findings suggest a

(1/9) A CMO data report on health trends and variation in England, 2025 provides a snapshot on health. I pull out some of the key data in the thread below. gov.uk/government/pub…

🚨 BAD news for Medical AI models. MASSIVE revelations from this Microsoft paper. 🤯 Current medical AI models may look good on standard medical benchmarks but those scores do not mean the models can handle real medical reasoning. The key point is that many models pass tests

I spoke to Sky News this morning Raising expectations without any support GP online access is a good thing but it needs extra GPs & resources The 8am rush may reduce but there are no more appts or Hp time to offer, in fact less as a online forms are dealt with Safety vital

📢 Semaglutide in non-overweight people with T2D 📊 Retrospective TriNetX study (BMI <25 kg/m²) 🩺 3-year outcomes •All-cause mortality: 6.1% vs 10.7% (HR 0.54, 95% CI 0.45–0.65) ✅ •AMI: NS •Stroke: NS •Adverse events: No significant difference 💡 Semaglutide associated

UTI is uncommon with SGLT2i - mycotic infections are common This study has important clinical implications ⚠️ After UTI, 1 in 3 patients stopped SGLT2i Discontinuation led to higher CV & renal risk, with no reduction in recurrent UTIs. 💡 Following UTI - continue SGLT2i

Today we have published the Medium Term Planning Framework for NHS England, marking the beginning of a new way of working in the NHS. This is the most ambitious plan the NHS has published in a generation. Read more ➡️ england.nhs.uk/publication/me…

🚨 “SGLT2 Inhibitors: The Unexpected Uric Acid Hack?” These glucose drugs don’t just lower sugar — they also drop uric acid levels by tweaking renal transporters & purine metabolism ⚡️ 💡 Mechanism = ↓ URAT1 / GLUT9 + ↑ excretion + ↓ production 📖 Packer M, JACC 2024

Impact of Traditional Risk Factors on Atherosclerosis Distribution 1️⃣ LDL-C >3 mmol/L 2️⃣ Systolic BP >140mm Hg 3️⃣ Smoking Maciej Banach Dr. Spencer Nadolsky Dr. Spencer Nadolsky Gil Carvalho MD PhD🌈🇵🇸 academic.oup.com/eurjpc/advance…