We are looking for postdocs to join our team! (please help spread the word).

The first and main story of my PhD research is now available on bioRxiv (!!!) Let me walk you through the main takeaways of my single-cell investigation of Spinocerebellar Ataxia Type 7 (SCA7) biorxiv.org/content/10.110…

Thrilled to share our human genetics discovery of the protective association between rare variants in CHRNB2 (encoding a subunit of nicotinic acetylcholine receptors) and smoking addiction, now out in Nature Genetics. See the reply for a detailed thread. Below is a short summary.

It's #HHTGlobalAwarenessDay & #HHTAwarenessMonth. People with HHT may develop multiple #AVMs, which can rupture & bleed. Our HHT Program allows patients to see an integrated team of specialists & is designated as a Center of Excellence by Cure HHT: BarrowNeuro.org/HHT

Several years ago, I wrote a 2-page guide on how to give a killer narratively-driven scientific talk. I called it "The David Attenborough Method", in homage to the master storyteller. x.com/wc_ratcliff/st… I recently expanded upon it in a short essay: authors.elsevier.com/a/1hRhv5Eb1BZj…

One more exciting piece of news today: our latest paper has just gone online! We're excited to introduce Gonomics, a platform for genomics and bioinformatics software development in the Go programming language! 🧵 academic.oup.com/bioinformatics…

With the first tweet of 2024, I am happy to announce that I am officially starting my lab Brigham and Women's Neurology next month: khoshkhoolab.com. We are recruiting at every level, but particularly looking for talented postdocs and a lab manager, please RT and spread the word.

We are hiring! My lab at Boston Children's Hospital/Harvard Medical School and Khoshkhoo lab Sattar Khoshkhoo at Brigham and Women's Hospital/Harvard Medical School are seeking postdocs with a focus on somatic mutations and neurologic diseases. nature.com/naturecareers/…

Jointly with August Huang August Yue Huang we are looking to hire a postdoc in computational genomics. This position is great for candidates who want to gain expertise in analyzing novel single cell sequencing data to study somatic mosaicism in neurologic disease. Spread the word!

GATK yet again flouting VCF specs... It is already so dysfunctional they might as well make their own format and stop pretending to be a VCF

@cwhelan Breaking compatibility (with past GATK and other tools) at this scale was a dangerous move. I don't see "a very minor boost in efficiency" could justify the change. There are probably many other ways to make GATK faster. Nevertheless, it is probably too late to revert now.

Excited to share our new preprint on spatial single-cell analysis of human cortical development! We used #MERFISH to analyze 16 million cells, revealing surprisingly early prenatal specification of human cortical layers and areas. (1/11) #Neuroscience biorxiv.org/content/10.110…

Min Zhu et al. show that somatic mutations in PKD1 (POLYCYSTIN1) are selected for in chronically damaged livers because they promote hepatocyte clone fitness without driving carcinogenesis. This shows that some somatic mutations are beneficial. (1/8) cell.com/cell-metabolis…

I'm so excited to announce that the Song lab will be opening in July 2025 Harvard Department of Human Evolutionary Biology! We will investigate the genetic basis of how the human brain evolved. 🧬🧠 janetsonglab.com 1/4

Today in nature, we report a spatial single-cell atlas of human cortical development, revealing surprisingly early specification of human cortical layers and areas. We built an interactive browser to explore the spatial data: walshlab.org/research/corte… Paper link below👇

🚨 We’re hiring! The Qian Lab (CHOP Research & Penn Medicine ) is recruiting Postdocs and Research Technicians to study human brain development & neurodevelopmental disorders. 📍Philadelphia, Pennsylvania | 🧠 organoids, spatial omics, cerebral cortex