Excited to share my 1st-author work from the @arbelharpak Lab! We examine the accuracy of polygenic score (PGS) predictions across individuals in the UK Biobank. We make 3 observations that expose gaps in our understanding of PGS “portability”. biorxiv.org/content/10.110… (1/28)

Anyone have any good beginner tutorials/resources on regression and/or machine-learning you can share? Looking for resources to support colleagues who are newer to data analysis #phdlife #phdchat #MachineLearning

Many of my students struggle with the distinction between Ordinary Least Squares (OLS) and Maximum Likelihood Estimation (MLE). To clarify, we use an interactive #Python dashboard that fits parameters to a Gaussian distribution based on a given dataset. This visual approach

Thrilled to have contributed to this amazing work led by Jiacheng Miao Qiongshi Lu, now out in Nature Genetics nature.com/articles/s4158…

IGES conference swag has started early 😄 bonfire.com/international-… IGES

Terrific turn-out today at the IGES Annual Mentor/Mentee Luncheon! Big thanks to all the volunteers who helped make it happen IGES

Interested in learning about genetic prediction of hepatoxicity in cancer patients treated with immune checkpoint inhibitor, come stop by my poster (# 7016) on Nov 8th #ASHG24 Elad Ziv Dr. Melinda Aldrich, MPH, PhD

Integration of CSF proteomics, metabolomics and genetics identify causal and druggable targets for #Alzheimers disease The Cruchaga lab published two side-to-side manuscripts in Nature genetics (nature.com/articles/s4158…; nature.com/articles/s4158…). @WUADRC WashU Medicine Neurology

Thrilled to announce that our new Carlos Cruchaga lab manuscript detailing the proteogenomic landscape of human cerebrospinal fluid is now live at Nature Genetics. Many thanks to @WUADRC and WashU Medicine Neurology for supporting this work. 1/13 nature.com/articles/s4158…

I'd like to share our new lab publication Carlos Cruchaga on an atlas of CSF and brain metabolite quantitative trait loci. Special thanks to the mentorship of Carlos, and the instrumental contributions from both Chengran Yang and Dan Western. nature.com/articles/s4158…

check out our new preprint led by Yichao (Charles) Zhou and supervised by Mengjie Chen and me doi.org/10.1101/2024.1… where we present scPrediXcan which integrates deep learning and single cell expression data into a powerful cell type specific TWAS framework

If you are an early career researcher looking for opportunities to serve on a professional committee in the field of genetic epidemiology, open positions for IGES committees are available. More info on committees & application process: geneticepi.org/yic_position-o… IGES

I'm hiring a computational biologist interested in complex trait genetics using deep learning approaches. Reach out to me, if interested.

A new GWAS resource: a pheweb server hosting GWAS results of 100+ EHR phenotypes in >500,000 Han Chinese from the Taiwan Precision Medicine Initiative. pheweb.ibms.sinica.edu.tw Yang, Kwok, Li, Liu, Jong, Lee, et al. Nature 2025 nature.com/articles/s4158…

"An African ancestry-specific nonsense variant in CD36 is associated with a higher risk of dilated cardiomyopathy" nature.com/articles/s4158…