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12/2024 Issue ➡️ embopress.org/toc/17444292/2… new bacterial protein functions, growth difference corrections in genomics data, protein abundance estimate from RNA-seq, XCMS linked to METLIN, genetic variant pathogenicity prediction Cover: predicting 3D genome organization in cancer

The #ISSCR2025 program covers global breadth of stem cell research and regenerative medicine with 70% of the invited speakers as first-time ISSCR speakers. Grateful to the program committee, co-chairs Eugenia Piddini and Kathy Cheah and the ISSCR team isscr2025.org

Our November issue is online! ➡️embopress.org/toc/17574684/1… This month's cover highlights the article by T Ackermann et al showing that incorporation of selenium in selenoproteins is important for #TNBC to form colonies & lung mets. Scientific illustration by S. Tardito Center for Cancer Research MedUniWien

Please join us in congratulating our 2025 winner of the prestigious Fondazione Pezcoller-EACR Women in Cancer Research Award, Karin de Visser 👏 Our deserving winner will deliver her Award Lecture at the #EACR2025 Congress in Lisbon next year! eacr.org/pezcoller-foun…

We are excited to announce the 2025 SY-Stem Symposium! From March 12-14, we will explore the latest advances in Stem Cell Biology. Share the news and register online: sy-stem.org #events #biology #europe #research

A new therapeutic vulnerability for childhood cancer neuroblastoma? Tanmoy Mondal et al show MYCN creates undifferentiated state by recruiting inhibitable METTL3 and m6A deposition at posterior HOX genes embopress.org/doi/full/10.10…

#EMBO in🇮🇪! Honored to be part of this week’s delegation to inform on #funding programmes, #training opportunities, & exchange grants at the Royal Irish Academy Royal Irish Academy, Ollscoil na Gaillimhe | University of Galway, UCC Ireland! 🙏 to members Noel Lowndes, Uri Frank Uri Frank & Ruth Massey for hosting us!👏

Issue 3: Review: RNA dysregulation in neurodegenerative disease Resource: qTAG for adaptable CRISPR-based tagging Archaeal ESCRT-III remodels eukaryotic-like membranes Condensin modulated by SLiM interactors Cover: Lim-Rutherford-Dickens-Rawlins Lab et al embopress.org/toc/14602075/4…

Are you attending the #EMBOmetabolicDiseases meeting in beautiful Torremolinos? So is our editor Deniz Senyilmaz Tiebe! Talk to her if you are looking for a home for your paper or about scientific publishing. EMBO Events EMBO Press

Craig Thompson and coworkers review the diverse biosynthetic and signaling functions of the most nitrogen-rich amino acid, #arginine, in mediating mitochondrial #metabolism and gene expression in health and disease embopress.org/doi/full/10.10…

On International Day of Women and Girls in Science, we congratulate Asifa Akhtar Asifa Akhtar, who receives the FEBS | EMBO Women in Science Award: embo.org/press-releases… #11Feb #February11 #WomenInScience FEBS MPI of Immunobiology & Epigenetics Max Planck Society

CDK4/6 inhibitors transiently induce a senescence-like state in breast cancer cells, which however cannot be eliminated by senolytics - but Boshi Wang and colleagues Demarialab find that they are instead sensitive to lysosomotropic agents! ERIBA embopress.org/doi/full/10.10…

Proteogenomic analysis of evolved aneuploid cell lines & primary tumors reveals adaptive strategies for alleviating the consequences of aneuploidy in cancer – including increased expression of DNA replication and repair factors Zuzana Storchova and coworkers embopress.org/doi/full/10.10…

EMBO is on Bluesky, and we look forward to meeting you there! bsky.app/profile/embo.o…

Congratulations to Julia Vorhauser @mansfeldlab The ICR for winning the @EMBOReports poster award at #EMBOmetabolicDiseases !

We welcome Veit Buchholz, who also started work on January 1 as Head of Division at DKFZ. He investigates the stem-cell-like mechanisms that underly the generation and maintenance of immunological memory and strives to provide transformative improvements in the therapy of cancer.

Hansong Ma and coworkers identify POLDIP2 as a novel mitochondrial exonuclease interacting with CLPX protease and promoting elimination of paternal mtDNA during Drosophila spermatogenesis embopress.org/doi/full/10.10…

In issue 4: FAM134B isoforms control ER dynamics in myogenesis Bacterial virulence factor targets both neutrophils & complement system Special pericytes in pulmonary capillaries Cover: 1st plant spliceosome structure by Yichen Lu, Ke Liang & Xiechao Zhan embopress.org/toc/14602075/4…

Somatostatin released by pancreatic δ-cells triggers local cAMP and Ca2+ signaling in primary cilia of nearby β-cells, to modulate their function beyond acute suppression of hormone release Olof Idevall-Hagren and coworkers embopress.org/doi/full/10.10…

Synergistic & antagonistic activities of IRF8 & FOS enhancer pairs during an immune-cell fate switch Graf, Nikolaou et al show individual enhancers act as stage-dependent, dynamic safeguards during CEBPA-induced B-cell-to-macrophage transdifferentiation embopress.org/doi/full/10.10…