Higher-order oligomeric assemblies are common across immune systems in all domains of life... 𝘽𝙪𝙩 𝙬𝙝𝙮!? 🤔 Using recent insights into bacterial immunity, we discuss the possible evolutionary advantages of these fascinating architectures🧬🏛️: rb.gy/cbwxxp 1/5

TLR signaling is executed from within the myddosome, w/ MyD88 forming barrel-like structures that function as scaffolds for effector protein recruitment Jonathan Kagan nature Daniel Fisch nature.com/articles/s4158…

Nature research paper: Molecular definition of the endogenous Toll-like receptor signalling pathways go.nature.com/3RV6uBb