🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

Penn Medicine’s Carl June, MD, has won the 2024 Breakthrough Prize in Life Sciences for his work in CAR T cell therapy. T cell therapy marked a transformative moment in medicine & opened new possibilities for personalized therapies for patients worldwide. Congrats, Dr. June!

Beyond youth: Understanding CAR T cell fitness in the context of immunological aging - NEW by Julia Han Noll 🧵sciencedirect.com/science/articl…

Excited to share my Ph.D. work in Carl June lab showing uninhibited CD28 co-stimulation via CTLA4 disruption invigorates dysfunctional CART cells doi.org/10.1016/j.immu…

Want a comprehensive picture of fuel use (all of them) and #flux during cold exposure, in whole organism, using in vivo 13C tracing? check out our new paper in Cell Metabolism: authors.elsevier.com/a/1ht945WXUlSw…. MD-PhD star Marc Bornstein led the charge; great collab w Rabinowitz lab.

Meet @jonepstein1, the new interim dean at Penn’s Perelman School of Medicine inquirer.com/health/new-dea… via @phillyinquirer

Our latest review on peripartum cardiomyopathy #PPCM in NEJM this week -- review of mechanism, genetics, clinical management, epi and prognosis -- lots of unknowns, huge racial disparities. Hope you enjoy it! nejm.org/doi/full/10.10…

Autoimmune disease is the next frontier for CAR T cell therapy. News feature by Carrie Arnold nature.com/articles/s4159…

Judy Campisi was an extraordinary person and though her loss cannot be overcome, here is a piece on her that will lift your day. science.org/content/articl…

🩺 Penn Medicine spotlight: last night we recognized Dr. Carl June, the Director of the Center for Cellular Immunotherapies at the Perelman School of Medicine, and Director of the Parker Institute for Cancer Immunotherapy at the University of Pennsylvania. Dr. June is joined

It was great to speak with Brad Loncar @BiotechTVHQ about my thesis work in Carl June’s lab and about the initiative Kristen Hege started to support early career women here at the Center for Cellular Immunotherapies

New study in PNASNews from @CarlHJune, MD, Center Director for PICI Center Penn Medicine, and team reveals TP53 isoform Δ133p53α bolsters T cell fitness & reinvigorated CAR T cells from #CLL patients who previously didn't respond. pnas.org/doi/10.1073/pn… #immunotherapy #leukemia

Check out our latest paper, published Nature Communications. We show that STING activation induces IL18 secretion and thereby enhances CAR T function. Great collaboration between @CarlHJune lab and James Chen UT Southwestern Medical Center. Penn Medicine Penn Medicine MD Penn Postdoctoral Association nature.com/articles/s4146…

Published today PNASNews: We’ve combined CAR T cells with proton radiation! Great collaboration between @Costas_Koumenis and @CarlHJune labs. Yiannis (Ioannis) Verginadis Penn Postdoctoral Association Penn Medicine MD pnas.org/doi/10.1073/pn…

The remarkable mechanisms of SGLT2 inhibitors #heartdisease A robust specific off-target activation of PANK1 by SGLT2i promoting CoA synthesis and efficient fuel use in human hearts, a likely explanation for the clinical benefits of SGLT2i. biorxiv.org/content/10.110… The Arany lab

In the latest issue! Off-the-shelf CAR-T cells could prove paradigm shifting for autoimmune diseases dlvr.it/TD3pV4

It's exciting that we are now seeing multiple different groundbreaking interventions towards curing autoimmune diseases. Here's one path nature.com/articles/d4158… nature

Congratulations to the 6 Penn Penn Medicine honorees elected to the National Academy of Medicine! Election to National Academy of Medicine is considered one of the highest honors in the field of health & medicine. Check back this week as we profile each new member tinyurl.com/3k9c9932

Published today Nature Biotechnology: @CarlHJune and I reveal how CAR T cells are finally tackling solid tumors! Penn Postdoctoral Association Penn Medicine MD nature.com/articles/s4158…

Grateful to be named a 2024 RISE Scholar by Parker Institute for Cancer Immunotherapy, alongside this incredible group of researchers driving advancements in cancer immunotherapy. Honored to be part of this effort toward a future where all cancers are curable!

Excited to share my PhD thesis work with @CarlHJune now out as a preprint on bioRxiv! We show that engineering IL-9 signaling enhances CAR T cell antitumor efficacy by steering them toward potent memory and effector states. biorxiv.org/content/10.110…