New chemistry and chemical proteomic technology from our group on functional tyrosine profiling in proteomes and live cells. Congrats to Emmanuel, Hahm, Adam, and Jeff. Great job on all of your hard work! Nature Chemical Biology nature.com/articles/s4158…

Today we report in Nature Chemical Biology a collaboration led by Haoxin Li in Ben Cravatt's lab to illuminate functional and druggable cysteines in the human proteome by integrated base editing and activity-based protein profiling. nature.com/articles/s4158… PDF: drive.google.com/file/d/1hky1Ye…

#Technology Chemical tools to expand the ligandable proteome: Diversity-oriented synthesis-based photoreactive stereoprobes by Daisuke Ogasawara, Bruno Melillo, Ben Cravatt at Scripps Research Broad Institute Harvard Medical School MassGeneral News dlvr.it/TGwBK2