It is IMPOSSIBLE to not find a statistically significant link between any 2 random variables under multi-testing. I generated 9 pairs of totally random variables, picked the highest R^2, and it beats what you see in papers. #FooledbyRandomness

Dear MRTX1133, we hardly knew you. Still remains a very useful proof of concept agent to target KRAS G12D mutant pancreatic cancers in mice. Will keep seeing preclinical studies for a while, especially combinations.

#NEWS: Our targeted cancer therapy candidate for previously treated patients with advanced HER2 (ERBB2)-mutant non-small cell lung cancer (NSCLC) has been granted Priority Review from the U.S. FDA.   Learn more: go.boehringer.com/7CFqS

Nietzsche, go for a walk

Nathan A. Pennell MD, PhD, FASCO IASLC 👌 The “osimertinib” for HER2mut NSCLC.

603,628 KM² 🇺🇦🇪🇺

👩‍🔬 Our next Alumni Portrait is online! We spoke with former IMP postdoc Sabine Jurado about her time at the IMP, moving to industry, her work in oncology at Boehringer Ingelheim Ingelheim, and what it means to do good science! 👇 ➡️ Full interview: imp.ac.at/career/beyond/…

Molecular binding in aqueous solvent can be viewed not as an association reaction but as an exchange reaction in which some receptor–solvent and ligand–solvent interactions in the unbound state are lost to accommodate the gain of receptor–ligand interactions in the bound complex.

Nietzsche, four words

Jorgensen et al (JCIM 2025) #Permeability Benchmarking: Guidelines for Comparing in Silico, in Vitro, and in Vivo Measurements #cheminformatics #MedChem #CompChem #ADME #OpenAccess doi.org/10.1021/acs.jc…

"This is hard to accept in the age of the Internet. It has been very hard for me to explain that the more data you get, the less you know whats going on, and the more iatrogenics you will cause. People are still under the illusion that science means more data." - Taleb

"If you don't feel that you haven't read enough, you haven't read enough." - Nassim Nicholas Taleb

The composition of a chlorophyll molecule consists of a porphyrin ring linked to a central atom. This structural arrangement closely resembles the heme group present in hemoglobin, with the distinction being that heme's central atom is iron, whereas chlorophyll's is magnesium.

"In most debates, people seem to be trying to convince one another; but all they can hope for is new arguments to convince themselves." - Nassim Nicholas Taleb in The Bed of Procrustes

Zongertinib- highly effective AND well tolerated ErbB2 TKI WITH CNS activity from Boehringer-Ingelheim- to a thor oncologist this sounds like a beautiful zong …just in German! With RR of >70% and >12m PFS for pretreated pts w ErbB2 TKD-mutated NSCLC, zongertinib delivers a real

Zongertinib for HER2/ERBB2 NSCLC and Chinese Academy of Medical Sciences Professor Wang Xin: scmp.com/news/china/sci…

🌏 Make your mark in Melbourne! 🌏 We are looking for innovative researchers to join WEHI as Laboratory Heads and help lead the next wave of biomedical discovery. For more information and to apply 👇 wehi.edu.au/careers/make-y…

Australia completely lacks a dedicated training program for clinician scientists. With the vision and support of VMIAL Peter Mac Cancer Centre is extremely proud to announce the first clinician-scientist fellowship. If you meet the eligibility criteria PLEASE APPLY! nature.com/naturecareers/…

Zongertinib has the mildest side effects of any drug—ever—in the Exon 20 Group, and our HER2 Warriors cannot praise it enough. So grateful to John Heymach for being international PI of the practice-changing zongertinib study. #DAVALung

"A marker for a charlatan: someone who uses arguments type"this is the best model we have". Skin in the game pple use ONLY reliable models." - Nassim Taleb #SkinIntheGame