So cool!🥳 Our study is out Science Advances | Anti-inflammatory #Glucocorticoids by keratinocytes - a mechanism to control #skin #inflammation. Thx to former ugstuds Leo, Jasmin, Verena & all collaborators/mentors/friends Sarah Mundt & patients/hdonors! advances.sciencemag.org/content/7/5/ea…

News: Scientists design gene delivery systems for cells in the brain and spinal cord nih.gov/news-events/ne…

Yale and Google trained a 27B parameter model, C2S-Scale, to unify single-cell transcriptomics and biological language for deep reasoning across genes and cells. It outperforms prior models in interpretation, QA, and perturbation prediction using reinforcement learning

Online Now: Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma dlvr.it/TL15CD

Check out our new study Science Immunology, identifying a distinct molecular signature of treatment-refractory psoriatic arthritis patients🧬 It was an exciting and fun journey with Reut Tzemach, Chamutal Gur, Eyal David, Shuang-Yin Wang IdoAmitLab team

The skin, a peripheral neuroendocrine hub, produces glucocorticoids (GCs) to regulate homeostasis. It's deficiency results in inflammation🔥 We here show that this only occurs with barrier breach. Intriguingly, bodywide skin GC loss increased adrenal GCs (Skin-HPA axis?)🤯

My lab's first paper is out in nature. We show that lipoprotein uptake protects tumors from ferroptosis by delivering the lipid antioxidant α-tocopherol. Surprisingly, tumors use sulfated glycosaminoglycans—not canonical receptors—to capture lipoproteins. nature.com/articles/s4158…

Learning the language of T cell receptors through large-scale screening dlvr.it/TLJPd8

TAMing immunity through an unexpected source dlvr.it/TLKTfD

Thank you everyone for the amazing support, we will definitely need your help down the road. We will rebuild everything that is broken - because we are not done.

Protein structure ≠ protein folding/dynamics The new north star: energy‑landscape learning, rather than static structure prediction Next wave: AI that learns free energy for "true" inverse folding

Finally here! Our preprint on the MOSAIC, a multimodal adaptive optical microscope enabling non‑invasive in‑vivo imaging from molecules to organisms, is out. biorxiv.org/content/10.110… Eric Betzig Legant lab

Absolutely insane amount of data in this resource from Chris Mason The Spatial Atlas of Human Anatomy (SAHA): A Multimodal Subcellular-Resolution Reference Across Human Organs biorxiv.org/content/10.110… Spatial data on 15million cells from 100 donors across multiple ages, mainly GI

Enhancers, how do they work (in vivo)? To find out, we mutagenized 7 human enhancers comprehensively in 12bp blocks and scored for activity in developing mouse embryos. rdcu.be/erD22 nature #mutagenesis #noncoding #enhancers

Delighted to bring gene circuits into a wide array of primary cells where they can be used for safe, effective gene therapies. 🧵 (1/n) Tremendous work by lead author Kasey Love to dig into the details of these systems and figure out how to get these to work well! Original

Epigenetic reprogramming as a strategy for treating neurodegeneration 🧠 tinyurl.com/ys4eh9yw

Many have asked what is our secret recipe for recovery. In reality there is only one way- you start as fast as you can and slowly accelerate

CRISPR just scored its biggest win yet against Huntington's. The secret? A delivery system called RIDE that sneaks into neurons, makes its edit, then vanishes in 72 hours. Here's what happened 🧵👇

Just published in Nature (June 2025), Andersen et al. (E. Antonio Chiocca, MD, PhD, FAANS, Reardon, Fran Quintana Lab) developed a novel viral barcode interaction-tracing (RABID-seq) platform, uncovering previously unknown immunosuppressive interactions between astrocytes and glioblastoma (GBM) cells.

In the latest issue! Cross-organ metabolite production and consumption in healthy and atherogenic conditions dlvr.it/TMPKmR