🚨 Discover how intramolecular epitope spreading in PLA2R-associated Membranous Nephropathy escalates disease severity. As autoantibodies expand from CysR to CTLD domains, inflammation intensifies, driving proteinuria and reducing chances of remission. t.ly/tMLkH

1/14 🤔 Why do we use iodine as an intravenous contrast agent? The answer requires a review of the composition of the human body and a brief tour of one of my favorites, the Periodic Table of Elements.

"Drink more water!" It's the easiest health advice around. Tired? Headache? Trying to be like Tom Brady? Just drink more water. But as a nephrologist, I get asked all the time: How much is the right amount? And the truth is... we don't really know. 🧵

Basics of Glomerulonephritis (GN). GBM is key. All patterns can be explained by glomerular basement membrane (GBM) & type of injury. Let’s do one at a time CRESCENTIC GN 1. Results from breach/break of GBM (red arrow) 2. Injury is sudden & severe Eg-ANCA & anti-GBM GN

Proud to share our new paper: a road map to redesign nephrology clinical trials by pairing modern methodology and computational tools. With Francesco Pesce. shorturl.at/kDg50

The success paradox: better therapies → rarer events → longer, costlier trials. Our proposal: smarter trials, not bigger, use adaptive & pragmatic designs, eGFR slope as surrogate, RWE and continue DHT monitoring. Francesco Pesce shorturl.at/yEeC3

Now open access in NDT CKD of unexplained cause (CKDx): A consensus statement by the Genes &Kidney Working Group of the ERA 🧐Check also our 2 open access editorials on this innovative concept. ▶️academic.oup.com/ndt/article/do…