Excited to share our bioRxiv on longitudinal #singlecell mapping of T cells with novel #machinelearning methods! We found exhausted T cells with divergent dynamics and distinct circuitry defining #immunotherapy response in human #leukemia tinyurl.com/ybj7amed

Our paper, led by Pavan Bachireddy, looking at genomics of #CLL relapse post bone marrow transplant, out now in Science Translational Medicine. Thanks to all involved especially PeterK . stm.sciencemag.org/content/12/561…

1/ Can leukemic cell intrinsic features shape #bmt outcomes? Great team effort to address this in Science Translational Medicine! Thx to Wu lab, PeterK, Gad Getz Laboratory, @BeTheMatch, and #patients Dana-Farber for support! stm.sciencemag.org/content/12/561….

2/ #bmt (#alloSCT) can cure otherwise incurable blood malignancies, largely through destruction of leukemic cells by donor immune cells = graft-versus-leukemia (#GvL) effect.

Proud to be a part of this exciting study!

1/ Our work on adipocyte exosomes and breast cancer in type 2 diabetes, in Science Signaling. Full text at science.org/doi/10.1126/sc… Excited to share details from @naserjafari26 @kolla284 Allie Casey Bella Pompa Christina Ennis Dr Carla Mazzeo MSc, PhD Nabil Rabhi Stephen R Farmer

Fat cells from patients with #Type2Diabetes can “communicate” with #BreastCancer cells and promote their growth—a finding that might explain the link between metabolic conditions and breast cancer metastasis. fcld.ly/kv3jkbl Science Signaling

Racism affects all aspects of health. To solve disparities in healthcare we must solve the underlying discrimination that led us there.

New research identifies exosome-mediated cross-talk between #BreastCancer cells and fat cells altered by insulin resistance – potentially explaining the link between breast cancer #metastasis and conditions like #type2diabetes. Gerald Denis Boston Medical Center fcld.ly/246hx5c

Research highlight: Adipocyte-derived exosomes may promote breast cancer progression in type 2 #diabetes go.nature.com/3ExVIr7 Naser Jafari @kolla284 Allie Casey Bella Pompa Christina Ennis Dr Carla Mazzeo MSc, PhD Nabil Rabhi Stephen R Farmer Gerald Denis

.Thelma Perry Brown really brought the session home with a moving presentation on her & her family's experience with cancer and what needs to be done to make sure Black patients aren't left behind. Thank you for reminding us of why we do what we do as cancer researchers. #NCIJI2022

Excited to share our review that just came out in Frontiers - Endocrinology highlighting the perturbations to the #BreastCancer tumor microenvironment in #type2diabetes Ruben Dries Gerald Denis frontiersin.org/articles/10.33…

Honored to have the opportunity to share my research @NCICancerBio !! #womeninSTEM

🎉 My manuscript is now available on bioRxiv! 📄 We found that #exosomes from diabetic patients drive more aggressive breast cancers by altering tumor behavior & immune evasion in #organoids. Gerald Denis Boston University 🔗biorxiv.org/content/10.110… #CancerResearch #phdlife #womeninSTEM