DCAF16-Based Covalent Handle for the Rational Design of Monovalent Degraders dlvr.it/TB4fn7

Structural Dynamics of the Ubiquitin Specific Protease USP30 in Complex with a Cyanopyrrolidine-Containing Covalent Inhibitor dlvr.it/TB4rxL

Restoring susceptibility to β-lactam antibiotics in methicillin-resistant Staphylococcus aureus dlvr.it/TBFFW3

Direct RAS inhibitors turn 10 dlvr.it/TBH4Lr

Template-assisted covalent modification underlies activity of covalent molecular glues dlvr.it/TBLDj0

Identifying pharmacological probes for human proteins represents a key opportunity to accelerate the discovery of new therapeutics. High-content screening approaches to expand the ligandable proteome offer the potential to expedite the discovery of novel… dlvr.it/TBMH5v

Sophisticated natural products as antibiotics dlvr.it/TBN0rk

Graph neural networks for identifying protein-reactive compounds dlvr.it/TBQ5VL

Predicting the Intravenous Pharmacokinetics of Covalent Drugs in Animals and Humans dlvr.it/TBVMv1

Co-targeting SOS1 enhances the antitumor effects of KRASG12C inhibitors by addressing intrinsic and acquired resistance dlvr.it/TBWsbj

Discovery of Thioether-Cyclized Macrocyclic Covalent Inhibitors by mRNA Display dlvr.it/TBsdHB

Exploring 2-Sulfonylpyrimidine Warheads as Acrylamide Surrogates for Targeted Covalent Inhibition: A BTK Story dlvr.it/TBtTch

Multi-tiered chemical proteomic maps of tryptoline acrylamide–protein interactions in cancer cells [Evert Njomen] dlvr.it/TBtTfc

Electrophilic proximity-inducing synthetic adapters enhance universal T cell function by covalently enforcing immune receptor signaling [The Rullo Lab] dlvr.it/TBwHWd

Discovering Covalent Cyclic Peptide Inhibitors of 2 Peptidyl Arginine Deiminase 4 (PADI4) Using mRNA3 Display with a Genetically Encoded Electrophilic 4 Warhead dlvr.it/TC6Xvf

Discovery of a Covalent Inhibitor of Pro-Caspase-1 Zymogen Blocking NLRP3 Inflammasome Activation and Pyroptosis dlvr.it/TCCVwB

Aminomethyl Salicylaldehydes Lock onto a Surface Lysine by Forming an Extended Intramolecular Hydrogen Bond Network dlvr.it/TCP1hT

Targeted Protein Localization by Covalent 14–3–3 Recruitment dlvr.it/TCVVQX

SuFEx Chemistry Enables Covalent Assembly of a 280-kDa 18-Subunit Pore-Forming Complex dlvr.it/TCglxQ

From Mechanism-Based Retaining Glycosidase Inhibitors to Activity-Based Glycosidase Profiling dlvr.it/TCpjGx