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DNA supercoiling isn’t just tension—it’s regulation! Discover how topological stress shapes chromatin structure, gene expression, and even disease, with new insights into nucleosomes, motors, and topoisomerases. #DNATopology #Chromatin #GeneRegulation sciencedirect.com/science/articl…

🧵Have you checked out our recent article in Current Opinion/Research in Structural Biology? Follow along with this thread by Souparna Chakrabarty to learn about the Dysfunctional Protein-Protein Interactome (#dfPPI) - a #chemoproteomic platform sciencedirect.com/science/articl… 🧵(1/11)

Micronuclei—tiny nuclei with big consequences. Learn how chromosomal instability, nuclear defects, and ruptures in MN disrupt genome stability and gene regulation, even before rupture occurs. #GenomicInstability #Micronuclei #CellBiology #COSB sciencedirect.com/science/articl…

How is chromatin folded in single cells—and what does it mean for brain development? Explore cutting-edge methods for 3D chromatin analysis and their insights into neural function and disease. #Chromatin #3DGenomics #Neurobiology #COSB sciencedirect.com/science/articl…

An AI driven computational analysis of the biofilm regulatory Diguanylate cyclases of Vibrio cholerae: Possible drug targets to fight against global pandemic of antibiotic resistance published in Current Opinion/Research in Structural Biology doi.org/10.1016/j.crst… #cholera #biofilm

Viral DNA packaging motors are among nature’s strongest! Explore how new structural and computational insights are revealing how ATPase rings generate force and coordinate to pack genomes with precision. #Virology #MolecularMotors #DNAPackaging #COSB sciencedirect.com/science/articl…

DNA isn’t just for genes—inside or outside the cell! Explore how extracellular DNA forms novel nucleoprotein structures in both eukaryotes and bacteria, supporting survival and new biological functions. #DNA #ExtracellularDNA #Nucleoprotein #COSB sciencedirect.com/science/articl…

How does gene regulation balance specificity and flexibility? Explore how fuzzy, dynamic DNA–protein interactions shape chromatin remodeling, transcription, and repair via a continuum of binding modes. #GeneRegulation #DNA #FuzzyBinding #COSB sciencedirect.com/science/articl…

Unraveling chromatin at atomic detail! Discover how solid-state NMR is revealing the structure and dynamics of histones in densely packed nucleosomes—shedding light on gene regulation in the cell. #Chromatin #NMR #StructuralBiology #COSB sciencedirect.com/science/articl…

How does the cell fix replication errors? Discover new structural and single-molecule insights into DNA mismatch repair initiation by MutS and MutL, and how cells discriminate strands to ensure accuracy. #DNARepair #MMR #StructuralBiology #COSB sciencedirect.com/science/articl…

Stretched in nanofluidic channels, DNA reveals its secrets! Learn how this powerful method sensitively probes DNA–protein interactions at physiological conditions. #DNA #Biophysics #Nanofluidics #COSB sciencedirect.com/science/articl…

How does DNA replication begin? Discover how cryo-EM and single-molecule studies are revealing the dynamic assembly of helicases and pre-replication complexes at origins—across species. #DNAReplication #CryoEM #StructuralBiology #COSB sciencedirect.com/science/articl…

Pioneering transcription factors reshape chromatin! Discover how recent structures reveal diverse strategies TFs use to engage nucleosomes—bending DNA, binding histones, and driving cell fate changes. #TranscriptionFactors #Chromatin #StructuralBiology sciencedirect.com/science/articl…

Cracking the C2H2 zinc-finger code! Discover how recent structural studies reveal new insights into how the largest family of mammalian transcription factors achieves precise DNA recognition. #ZincFingers #TranscriptionFactors #StructuralBiology #COSB sciencedirect.com/science/articl…

Artificial intelligence methods for protein folding and design Current Opinion/Research in Structural Biology １．This review highlights a major paradigm shift: protein structure prediction models like AlphaFold2 (AF2) and RoseTTAFold have been successfully repurposed for de novo protein design. Innovations such

G-quadruplexes (G4s) are rising stars in therapeutic research! Explore how natural and synthetic G4s interact with proteins, revealing new insights into complex biology and inspiring next-gen drug design. #GQuadruplex #StructuralBiology #Therapeutics #COSB sciencedirect.com/science/articl…

Single-molecule fluorescence imaging (SMFI) is revealing how genome maintenance proteins interact with DNA in real time—uncovering the dynamic mechanisms behind genome stability. #SMFI #DNARepair #GenomeStability sciencedirect.com/science/articl…

Check out COSB collection on 3D Genome Chromatin Organization and Regulation: sciencedirect.com/special-issue/…