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Friday in the lab vibe... #AcademicChatter #lablife

As I look at my living room today, I reflect on the relativity of time during COVID...

Really pleased to see our J Med Chem paper online. We describe the development of high affinity, selective CREBBP/EP300 bromodomain ligands & evaluate their effects in HCT116 cells. Congratulations to all of the authors & our collaborators. #epigenetics pubs.acs.org/doi/abs/10.102…

Our paper on the CREBBP bromodomain is out! Check out how we improved affinity and selectivity by fine tuning intramolecular interactions pubs.acs.org/doi/abs/10.102… Collaboration between Stuart Conway @Hammond_Lab Will Pomerantz Robert Paton Pomerantz Lab

A really cool part of this work was understanding the effects of the intramolecular H-bonds on molecule conformation and therefore biological activity. In previous work (onlinelibrary.wiley.com/doi/full/10.10…) we showed that the intermolecular H- bond was beneficial for bromodomain binding.

I’m still amazed by the impact this 20 year old paper had on launching the #TPD field. Looking forward to all of the exciting innovation to come in the next two decades! #PROTACs

Interested in joining us to develop the next generation of proximity induced therapeutics or in using chemical biology to understand lysine post-translational modifications then please get in touch! burslemlab.com #chemjobs #chempostdoc

I'm just so tired of this shit. These are just the obvious ones- a thread lest we forget. David Sabatini- 2021 MIT/Whitehead/HHMI the-scientist.com/news-opinion/c…

🚨 Un groupe Telegram d’extrême droite fait des listes de juifs. Dans ce groupe on retrouve énormément de contenu faisant l’apologie du nazisme, de l’antisémitisme, de l’islamophobie et de la negrophobie. (J’ai masqué les noms)

Fall colours - lab edition

just a kind reminder! 2 POSTDOCS in MED CHEM are now available in my group! Apply here!!!

He was creating the building blocks for drug developers worldwide. Then Russia started to bomb Kyiv. Check out our recent story🇺🇦 statnews.com/2022/03/14/ukr…

2.5 years later - better late than never!

GP is hiring! Come join the dream team of induced proximity and help us change the world. jobs.prox.bio General Proximity

I'm hiring a principal scientist/director at General Proximity to take over my role of leading the absolutely stellar group of scientists on our platform team. Strong chem bio + proximity background is best, but leadership skills are most important. Please share + DM if interested, ty! :)

A little about our technology. GP was founded on a simple, first principles premise: Proximity is inarguably a key regulator of biology and all major disease processes. Yet only a minuscule fraction of existing drugs work through proximity.

Check out our Axios exclusive from @AxiosAaron today here: axios.com/pro/health-tec…

We are out of stealth!!