🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

We have 10 articles in a Special Collection on VPS13 and Bridge-Like Lipid Transfer Proteins: six original research and four reviews. Read our Editorial to find out more about them and to access them one by one. journals.sagepub.com/doi/10.1177/25…

There's a new paper from the @Oidevall group (Uppsala) who show that insulin granules form contacts with the ER where OSBP is recruited (Ca2+ and pH- dependent) to exchange granule PI(4)P for ER cholesterol, hence allowing normal insulin secretion.

New work from the Imperi group #Roma3 study phospholipid traffic in Pseudomonas. Four out of the seven AsmA homologs (tamB, yhdP, ydbH, PA4735) are redundantly essential (at least one is required). There is rescue by lower LPS delivery, showing balance between the 2 OM leaflets.

The group of Natividad Ruiz Ohio State have further mapped the role of RBG proteins in bacterial lipid traffic An RBG protein too short to cross the periplasm functions only when a protein in the same operon augments the b-structure to complete the bridge pnas.org/doi/10.1073/pn…

The team of Lackner Lab at Northwestern University have shown that 3 way mitochondria/plasma membrane/ER contacts in yeast need the tether Num1 to bind VAP. Their outputs include regulating PI4P at the PM and mitochondrial division. The team offer lots of ideas for future work.

New article out in Contact - a mini-review with the "news"* about Spartin *almost 5 months old

The Meyer lab Weill Cornell Medicine show ER-PM contacts are involved in cell migration. Contacts are static in relation to cell matrix, so as a cell moves contacts go to the back. They turn off EGFR signals via PTP1B, propelling cells forward. See paper for details on contact asymmetry.

The membrane contact site meeting in Edinburgh is coming up soon: Sept 23-25 And the deadline for abstracts is less than 2 weeks away: July 23 Since we have lots of slots for oral communications, get your abstract in now. Early bird discount same date bit.ly/Membrane24

Deadlines for abstracts and early-bird registration have been extended until 31 July 2024.... There are still 5 days left: eventsforce.net/biochemsoc/fro… ...see how the two halves of the hourglass are making a contact site?

We have a new review out from Tadashi Makio & Thomas Simmen UAlberta Med & Dent Not So Rare: Diseases Based on Mutant Proteins Controlling Endoplasmic ReticulumMitochondria Contact (MERC) Tethering journals.sagepub.com/doi/full/10.11… Common features of rare diseases may help lead to treatments

We have 2 new articles out: Vesa Olkkonen University of Helsinki & Elina Ikonen IkonenLab have written a perspective reviewing the Oxysterol Binding Protein family journals.sagepub.com/doi/full/10.11… Wei-Ke Ji (Huazhong University of Science and Technology, Wuhan) and colleagues have reviewed SMP proteins journals.sagepub.com/doi/full/10.11…

Our most recent article is out: Johannes Frietag Thorsten Stehlik & Gert Bange (Marburg) describe a simple, powerful mechanism they recently uncovered for interaction between organelles: proteins with targeting sequences for both organelles are pulled both ways at the same time!!

The team of Mark Von Zastrow UCSF Psychiatry and Behavioral Sciences show that one aspect of cAMP compartmentalization is through specific intracellular targeting of adenyl cyclases. "these results reveal a precise spatial landscape of the cAMP cascade" nature.com/articles/s4146…

Our latest article about proteostasis pathways shared between organelles is from Andreas Kohler & Verena Kohler Umeå University. They address how proteostasis requires both major signalling processes (integrated stress response (ISR), UPR + more) and also direct physical contact.

Did you know we are the only journal dedicated to research on membrane contact sites? And yet the scope is wide - from lipidology to applications in human disease. Check it out: journals.sagepub.com/overview-metri…

We have a new review from Rajendra Angara, Margaret Sladek & Stacey Gilk Dr. Stacey Gilk (UNMC) about how intracellular pathogens parasitise the interface between lipid droplets and the ER journals.sagepub.com/doi/full/10.11… Their focus is on the differing strategies of SARS-CoV-2 and Coxiella

Contact across kingdoms: Rickettsia Parker intracellular parasites sit in the cytoplasm and form stable contacts with the endoplasmic reticulum.

We have a new article from Emma Fenech, Maya Schuldiner & co. (Weizmann, Rehovot) on the yeast LAM family of sterol transfer proteins. They use proximity labeling to compare all 6 proteins, finding unique functions for paralogs and new functional links. journals.sagepub.com/doi/full/10.11…

Another new article: Ida J. van der Klei and colleagues (Groningen) show the Pex23 family of ER proteins with dysferlin domains have unexpected roles in aspects of lipid droplet function that are suppressed by an artificial ER-mitochondrion tether. journals.sagepub.com/doi/full/10.11…

A 3rd new article: the teams of Laura Lackner (Norhtwestern) and Tom Burgoyne (UCL) jointly review zones of contact between mitochondria and the plasma membrane across a wide variety of organisms, speculating on unknowns and discussing unanswered questions journals.sagepub.com/doi/full/10.11…