Excited to share our story in Cell Reports. We looked at how microglia influence mammalian retinal regeneration. We find microglia and neuroinflammation restrict neurogenic reprogramming of mouse Muller glia. #retina #glia #microglia #regeneration cell.com/cell-reports/f…

In our work out in @Cellreports we have made significant strides in regenerating neurons from glia. We find the combination of Ascl1 with Atoh-transcription factors significantly improves the ability of Muller glia to regenerate neurons. cell.com/cell-reports/f… Quick summary:

Finally out in Developmental Cell! authors.elsevier.com/a/1elqV5Sx5gq6… Eric Thomas @three1st_names first-authored this work which represents the awesome power of collaborative science with the groups of kevin eade, @SethBlackshaw, and Melanie Bahlo.

Very excited to share the SEACells method to identify granular metacells from single-cell data.

If you are attending ARVO this upcoming week and are curious to see what the Reh lab has been up to, please stop by and see us. Four of us will be presenting! (details below)

Our newest endeavor to regenerate neurons from glia is out now Science Advances. In this paper we try and coax Muller glia to regenerate retinal ganglion cells (Brief overview below) science.org/doi/10.1126/sc…

Thrilled to announce our last paper is out!! 🎉 Check this out 👀 ASCL1 induces neurogenesis in human Müller glia Stem Cell Reports cell.com/stem-cell-repo… Great team effort Connor Finkbeiner Alex Haugan Isabel Ortuño @GoldenNeuron Thomas Reh

🚨New #preprint alerte💡 For the first time, we show reprogramming of human Muller glia in 3D, using a novel glia/progenitor driver of proneural genes. This approach could accelerate human retina regeneration in the *near* future! 👀‼️ Check it out: biorxiv.org/content/10.110…

First paper from our new lab! We found that invasion of peripheral immune cells into the retina make it harder for glia to regenerate neurons. SfN Journals Upstate Research NEI jneurosci.org/content/early/…