An unexpected corridor to #brainmetastasis: #breastcancer cells (BCCs) migrate from the bone marrow to the leptomeninges. ow.ly/UWFn50SOgHa Andy Whiteley, PhD @dukecancer Duke Department of Medicine

>180 million (about 60%) of US adults will have some type of heart or vascular disease, including high blood pressure, by 2050, according to projections. Costs will total about $1.8 trillion annually by 2050, per study in Circulation ow.ly/4z0l50SP8Kf #heartdisease

Pro-angiogenic/arteriogenic monocytes (PAMs) injected into human ischemic limb muscles were retained near the site for up to 72 hours; using patient-derived PAMs could be a therapeutic approach for treating chronic limb-threatening ischemia (#CLTI). ow.ly/5PgL50SOkO6

Women are still underrepresented in medical device trials: a review of 195 trials evaluating medical devices, most from 2013-2022, found that only ~1/3 of participants were women, with the largest disparity in cardiovascular device trials. JAMA Internal Medicine ow.ly/QxLU50SOorq

The World Health Organization (WHO) Director-General declares #mpox outbreak a public health emergency of international concern. who.int/news/item/14-0…

More than half of US states reporting 'very high' #COVID activity levels according to @CDC #wastewater data. cdc.gov/nwss/rv/COVID1…

17 #cancer (s) on the rise in younger generations: US study suggests cancer rates are increasing in millennials and Gen-Xers, with over half linked to obesity. thelancet.com/journals/lanpu…

Oropouche virus disease (#OROV) imported to the EU for the first time: 19 cases of the zoonotic disease were reported, in people with travel history to Cuba and Brazil. ow.ly/NShS50SWXO9

Oropouche virus surging in Latin America may harm fetuses: virus could be linked to brain malformation and stillbirths, including microcephaly. ow.ly/oq7850SWYSZ. #OROV

A study of 10,000 patients at 83 U.S. clinics found that none of 25 routine lab tests were clinically useful for diagnosing #longCOVID.. The search for a clinically useful biomarker continues. ow.ly/lxi650SWUq7

Understanding mechanisms of #GLP-1 drugs: Study shows GLP-1 increases preingestive satiation via hypothalamic circuits in mice and humans via GLP-1 receptor neurons in the dorsomedial hypothalamus. ow.ly/QEEe50SWYr9 #GLP1Drugs

First nasal spray drug for emergency #allergicreactions gets FDA approval, providing a needle-free alternative for #epinephrine administration to treat #anaphylaxis. ow.ly/Mgib50SWWCN

Cancer cases and deaths in men predicted to increase by 93%, and #cancer disparities will also widen by 2050. American Cancer Society Society states that promoting universal health coverage will be crucial to ensure cancer equity. ow.ly/i2ma50SWVBC

Study reveals that a population of neurons in the infant mouse brain (somatostatin-expressing neurons in the zona incerta) coordinates the positive effects of the relationship with the mother on an infant’s behavior and physiology. ow.ly/427Q50SYrhw

Pain and inflammation cross-talk – #nociceptor activation in the gut can exacerbate #inflammation through release of neuropeptides (CGRP,SP), dilation of blood vessels and plasma leakage, degranulation of mast cells, and ⬇️ proliferation of #Treg cells. ow.ly/7cos50SX1j9

The startling toll of SARS-CoV-2 is still with us: nearly 1.2 million people in the US have died from #Covid19, and 1/3 of people report losing a close friend or relative. “The pandemic had characteristics of a collective traumatic event.” nejm.org/doi/abs/10.105…

Primed for pain by #sleepapnea: During sleep, mice exposed to #hypoxia, but not those roused the same # of times, were more sensitive to heat and touch. Hypoxia activated peripheral macrophages and promoted their recruitment into sensory nerve tissues. ow.ly/2cj950SWZpZ

Landmark trial may herald new era in #HIVprevention – twice yearly #lenacapavir injections provided 100% protection for women in study conducted in Africa. #WomensHealth #HIV NEJM nejm.org/doi/full/10.10…

The lasting effects of famine – consistent with observations in other countries, early exposure to food scarcity during the Ukraine famine of 1932-1933 increased risk of adult type 2 diabetes later in life, with a dose-response relationship. ow.ly/SHJX50SYwUN

HHS to fund new US rural medical residency programs – more than $11 million will go towards launching residency programs in rural communities throughout the country. Currently, only ~2% of medical residency training happens in rural areas.