📣 Our PhD program is now open for admissions! 🎉 hunimed.eu/course/phd-in-… We have exciting projects on T-cell responses in cancer immunotherapy, with a focus on genome integrity and regulation of effector functions. APPLY!

🚀 Excited to share our new paper on Cancer Communication! Christoph Heuser-Loy from the T-FITNESS consortium comments on a recent study in National Centre for Biotechnology Education nature.com/articles/s4158… on the potential of IL-10 transgenic CAR T cells. #innovation #immunotherapy Horizon Europe 🇪🇺 European Innovation Council

A Universität Regensburg team used single-cell chromatin accessibility data, including the #TransposableElement landscape of CD45+ immune cells from colon, skin, adipose tissue, and spleen, finding organ-specific and conserved features across immune cells. bit.ly/4dcAros

We are advertizing a #PhD position in our lab to study evolutionary genetics of adaptive immunity in humans and/or fish. We use computational and molecular approaches. Topic open, to be matched with student's interest/skills. Come join us! #MHC #HLA #TCR uni-hamburg.de/en/stellenange…

Boosting the therapeutic potential of anti-Tumor T cells by ectopic expression of the small, regulatory protein Lmo4 Check out the new study from the lab spearheaded by Roland Schelker #syntheticbiology #Tcelltherapy

Our latest paper "NaCl enhances CD8+ T cell effector functions in cancer immunotherapy" is now out Nature Immunology nature.com/articles/s4159… 🥳🎉🍾. A 🧵:

Pharmacological inhibition of LSD1 in CTL in context of adoptive T cell therapy enhances function & antitumor immunity in female mice, acting synergistically with anti-PDL1 vs melanoma nature.com/articles/s4146…

Mitochondrial tonic for adoptive T cell therapies dlvr.it/TDTfLL

#NatMetabPicks | In Cell by J Baldwin, Christoph Heuser-Loy, L Gattinoni (@presse_UKR): Mitochondrial transfer to CD8+ T cells increases mitochondrial content, improves their metabolic fitness and boosts antitumor responses. #cancer #mitochondria cell.com/cell/fulltext/…

Like a SciFi movie where injections change behavior - Intercellular nanotube-mediated mitochondrial transfer enhances T cell metabolic fitness and antitumor efficacy Cell Press sciencedirect.com/science/articl…

🤝 Today and tomorrow, we are hosting the 2nd Annual Meeting of the T-Fitness Consortium in Sitges! Welcome to all collaborators —we are excited to share our advancements. Together, we’re revolutionizing cancer immunotherapies by creating T cells resistant to exhaustion 💉🏃

This week: mitochondrial transfer can enhance #Tcell fitness! 🛣️ A team at the Leibniz Institute for Immunotherapy and National Cancer Institute found intercellular highways that transport stromal cell mitochondria into CD8+ T cells. 📑 - bit.ly/3BDsqeG 💬 - bit.ly/4eUpWqO

Laub könnte ein Symbol der Gelassenheit sein, ein Problem des Herbstes, das sich im nächsten Frühjahr von selbst erledigt. Wie im Wahn stopfen deutsche Hobbygärtner es stattdessen in Plastiksäcke, schaufeln, blasen und saugen es aus der Welt. Muss ja. trib.al/sZtU0kt

In the latest issue! Intercellular nanotube-mediated mitochondrial transfer enhances T cell metabolic fitness and antitumor efficacy dlvr.it/TGC0dP

Thanks Cosima Baldari Trends in Immunology for highlighting our recent work Cell and Paolo Ruggiero for the great illustration!

In a surprising paper published in Nature, scientists accomplished what sounds impossible: using genes from a single-celled organism to create mouse stem cells, which eventually developed into a living, breathing mouse.