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Check out TPCB student Christian F. Baca's latest paper in Cell! Christian discovered a new mechanism by which bacteria fight viral pathogens. This work was completed through a collaboration with the Marraffini, Patel, and Brady labs at Rockefeller and MSK lnkd.in/eXT4j4iK

CRISPR has long been likened to a kind of genetic scissors, but a study from the @MarraffiniLab found that CRISPR-Cas10 employs an additional strategy to protect against viruses: a molecular fumigator. #RockefellerScience #yearinreview rockefeller.edu/news/36859-a-n…

Thrilled to share that I’ve been named an HHMI Hanna Gray Fellow! 🎉 I’m so excited to be joining this incredible community of scientists. Many thanks to @HHMINews for this opportunity and my mentors Lydia Finley and @MarraffiniLab ! #HannaGrayFellows

Many thanks to the Xu Peng lab and Cell Host & Microbe for the very nice preview of our recent story!

Very happy to share our new review in Molecular Cell covering nucleic acid recognition and effector mechanisms for various prokaryotic immune systems! Was a great experience creating this with @MarraffiniLab! cell.com/molecular-cell…

In this review for our focus issue on patterns in molecular biology, @MarraffiniLab talks about the mechanisms of patterns recognition by which bacteria differentiate between self and non-self molecules to regulate the activation of immune responses. cell.com/molecular-cell…

Know the feeling when two things look similar, and yet turn out to be quite different? Seems like defense-associated reverse transcriptases will continue to surprise us... Another thrilling story uncovered in collaboration with Wiedenheft Lab! Check it out:

Cat1 forms filament networks to degrade NAD+ during the type III CRISPR-Cas antiviral response Science Magazine Puja Majumder Christian F. Baca @MarraffiniLab science.org/doi/10.1126/sc…

CRISPR associated filament networks providing antiviral immunity! I am very excited to share our recent work co-led by amazing Christian F. Baca and me. The work is now online in Science Magazine! Science.org/doi/10.1126/sc…

Excited to share our last collab paper, now out in print Science Magazine!🎉 We reveal how dITP synthesis activates a SIR2 NADase effector to block phage infection! 🛡️🧬 science.org/doi/10.1126/sc…

A CARF-HAD phosphatase effector provides immunity during the type III-A CRISPR-Cas response | bioRxiv biorxiv.org/content/10.110…

Activation of bacterial programmed cell death by phage inhibitors of host immunity dlvr.it/TKZ0TY

1/10 Today in Science Magazine in collaboration with liugroup we report the development of a laboratory-evolved CRISPR-associated transposase (evoCAST) that supports therapeutically relevant levels of RNA-programmable gene insertion in human cells. drive.google.com/file/d/1I-UbCR…

A study from the #MarraffiniLab in Science Magazine shows that newly discovered weapons of bacterial self-defense take different approaches to achieving the same goal: preventing a virus from spreading through the bacterial population. Learn more: bit.ly/4dvmBij

Take a look on our recent work on expanding the CRISPR-toolbox! The work is highlighted by The Rockefeller University! Huge thanks to the co-lead author Christian F. Baca, Dinshaw Patel lab (MSKCC) and Luciano Marraffini lab (RU)! rockefeller.edu/news/37733-res…

Rockefeller's Luciano Marraffini has been named a member of the 2025 Class of #GreatImmigrants, Great Americans by the Carnegie Corporation of New York! Born in Argentina, Luciano is recognized for his work on CRISPR-Cas systems. Congrats! For more details, see: carnegie.org/awards/award/g…