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Interesting findings on predictors of response to sotorasib—worse outcomes with Keap1, worse tox w prior PD1 within 12 wks. Re Keap1, Nrf2 signaling as bypass mechanism? JCO Precision Oncology #ASCO23 Memorial Sloan Kettering Cancer Center

Great to see this story out—fascinating demonstration of APOBEC3A driving resistance to targeted therapy in the persister state. Great effort from Hideko Isozaki, Hata lab, MGH Thoracic Oncology and the EGFR/ALK teams.

Excited to present our research showing high Trop-2 expression in thymic epithelial tumors Lung Cancer Journal Great work by Dr. Vincent Yeung, former fellow Georgetown Lombardi A multicenter IIT of sacituzumab govitecan in TETs under design by Jennifer A. Marks, MD! bit.ly/3s3Z6cH