Brett Chrest (@chrest_brett) 's Twitter Profile
Brett Chrest

@chrest_brett

PhD student with expertise in Mitochondrial Bioenergetics & Cancer Metabolism with @KFW_Labโ”ƒ Investigating Ketones, Diet, Microenvironment & Cancer/AML๐Ÿฉธ

ID: 1621753549

calendar_today26-07-2013 01:43:08

15,15K Tweet

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Prof. Nikolai Slavov (@slavov_n) 's Twitter Profile Photo

According to DNA methylation "aging clocks", physical activity "rejuvenates" athletes immediately after the game. ๐”๐ฉ๐จ๐ง ๐ซ๐ž๐ฌ๐ญ, ๐ญ๐ก๐ž ๐ซ๐ž๐ฃ๐ฎ๐ฏ๐ž๐ง๐š๐ญ๐ข๐จ๐ง ๐๐ข๐ฌ๐š๐ฉ๐ฉ๐ž๐š๐ซ๐ฌ. This is inconsistent with my definition of aging. ๐Ÿงต

According to DNA methylation "aging clocks", physical activity "rejuvenates" athletes immediately after the game.

๐”๐ฉ๐จ๐ง ๐ซ๐ž๐ฌ๐ญ, ๐ญ๐ก๐ž ๐ซ๐ž๐ฃ๐ฎ๐ฏ๐ž๐ง๐š๐ญ๐ข๐จ๐ง ๐๐ข๐ฌ๐š๐ฉ๐ฉ๐ž๐š๐ซ๐ฌ.

This is inconsistent with my definition of aging.

๐Ÿงต
Eric Betzig (@eric_betzig) 's Twitter Profile Photo

MOSAIC large field of view 3D single molecule localization microscopy of mitochondrial outer membranes and nuclear membranes in fixed U2OS cells.

Kentsis Research Group (@kentsisresearch) 's Twitter Profile Photo

Prof. Nikolai Slavov While whole-genome sequencing using Illumina is commonly described as such, in reality, it is closer to half genome sequencing due to limitations of sequencing (GC content) coverage, not to mention variant calling limitations that you allude to.

Tanentzapf Lab (@tanentzapflab) 's Twitter Profile Photo

The goal of a PhD is not to learn some facts or read a few papers or learn a bunch of techniques. The goal of a PhD is to learn independence, problem solving, how to finish things you start, resilience, & gain the ability to adapt & think creatively. Learning these things is hard

Brett Chrest (@chrest_brett) 's Twitter Profile Photo

Common thought is diabetes & obesity would be worse for cancer due to increased supply of glucose for the tumor. However, using a breast tumor model, diabetic obese mice have no difference in tumor glucose metabolism compared to control diet. link.springer.com/article/10.100โ€ฆ

Itai Yanai (@itaiyanai) 's Twitter Profile Photo

A great thing about working in a lab is being involved in lab meetings and witnessing everyone's projects take shape. A single project may seem to go slow but all projects together is impressive. Caroline Bartman discussed this on the podcast: podcasts.apple.com/us/podcast/28-โ€ฆ

A great thing about working in a lab is being involved in lab meetings and witnessing everyone's projects take shape. A single project may seem to go slow but all projects together is impressive. Caroline Bartman discussed this on the podcast: 
podcasts.apple.com/us/podcast/28-โ€ฆ
David M. Sabatini (@dmsabatini) 's Twitter Profile Photo

Congratulations to โฆMax Valenstein, MD, PhDโฉ and Max Wranik and senior author Kacper Rogala on this beautiful work showing in atomic detail how amino acids activate mTORC1 via GATOR2. nature.com/articles/s4158โ€ฆ

Saez-Rodriguez Group (@saezlab) 's Twitter Profile Photo

We present our MetaProViz #Rpackage for #metabolomics analysis & prior knowledge integration to generate mechanistic hypotheses on how metabolic changes affect metabolite classes, pathways & environment interaction ๐Ÿ”—biorxiv.org/content/10.110โ€ฆ ๐Ÿ“ฆ saezlab.github.io/MetaProViz/ ๐Ÿงต Thread

We present our MetaProViz #Rpackage for #metabolomics analysis & prior knowledge integration to generate mechanistic hypotheses on how metabolic changes affect metabolite classes, pathways & environment interaction

๐Ÿ”—biorxiv.org/content/10.110โ€ฆ
๐Ÿ“ฆ saezlab.github.io/MetaProViz/
๐Ÿงต Thread
Brett Chrest (@chrest_brett) 's Twitter Profile Photo

Caution around isolated enzyme experiments, I love this example: SUCL activity is due to succinyl-CoA production from AKGDH. Thus you can genetically down regulate AKGDH, isolate mitochondria and test maximal SUCL activity and see no difference. pmc.ncbi.nlm.nih.gov/articles/PMC36โ€ฆ

Eric Topol (@erictopol) 's Twitter Profile Photo

And here how brain tumors exploit glucose for their growth, along with a dietary restriction of an amino acid therapy to prevent it nature.com/articles/s4158โ€ฆ

And here how brain tumors exploit glucose for their growth, along with a dietary restriction of an amino acid therapy to prevent it
nature.com/articles/s4158โ€ฆ
Brett Chrest (@chrest_brett) 's Twitter Profile Photo

Slight caution: Labeling glutamine, blocking glutaminase, and *only* looking at labeled extracellular succinate might not give clear insight into the mitochondrial pathway. AKG can be exported & converted to succinate outside of the mito. nature.com/articles/s4146โ€ฆ

PBS News (@newshour) 's Twitter Profile Photo

One of the country's foremost food policy experts said Tuesday that HHS Secretary Robert F. Kennedy Jr.'s Make America Healthy Again report is "a report about intentions. It's not about actions." "What you wonder is, how on earth are they going to do these things? What do they