Our latest from James Briscoe lab: How temporal & spatial pattering cues are integrated in the vertebrate neural tube to organise cell type generation during development.

biorxiv.org/content/10.110…

Outstanding PhD work by our super-talented Lucia Del Valle, with the help of superb collaborators at Instituto de Neurociencias UMH-CSIC MPI for Biological Intelligence Universität München
LifeHUB.CSIC CSIC SENC
science.org/doi/10.1126/sc…

Happy to see our new story published. 3 types of cortical Radial Glia Cells revealed: alpha, beta and gamma, with different amplificative behavior and involved in different cell lineages, that run together and in parallel in different germinal layers. Ferret is a superb model (1)

Using in vivo CRISPR perturbation, lineage tracing, and ChIP–sequencing provides insight into how inhibitory neuron identity is determined in the developing germinal zone

Elena Dvoretskova • Christian Mayer (@[email protected]) • MPI for Biological Intelligence

nature.com/articles/s4159…

Looking forward to diving into the final version of this work. Excited that others also find differential binding as a chromatin strategy for alternative cell fate choice.

Excited our paper got published! 🎉 Diving deep into the biology of transcription factors and their evolution was mind-blowing. They're the maestros orchestrating how we function today!

A team led by Christian Mayer discovered that a protein called MEIS2 plays a crucial role in the formation of GABAergic projection neurons. These neurons enable various brain functions, and a failure of MEIS2 to control their development may contribute to neurodevelopmental

How does the competence of GABAergic progenitors change in time? It depends on whether you're looking at maturation or differentiation! Check out our new preprint: doi.org/10.1101/2024.0…
Big shoutout to the amazing contributors, esp. Yana Kotlyarenko ann rose bright, Flo, Diana!

Unravelling brain development: Watch Ann and Yana in their daily lab routine! 🧠🤯 Using methods such as genetic fate mapping and single-cell RNA-sequencing, the Mayer lab seeks to understand cellular decision-making during interneuron development.

Christian Mayer (@[email protected]) ann rose bright

On my way to pick up Gord Fishell from his hotel. He is today's speaker at the MPI-BI Keynote Lecture Series. His talk is at 14:00 in room NQ105 at the MPI for Biological Intelligence.