Beyond thrilled to have our research published in Science Signaling AND to get the front cover 🤯🔬 The teamwork that went into this paper is something that we’re all very proud of🧪Chris Hoyle Jack Green Antony_GEU Billie Matchett, PhD G. Lopez-Castejon

Happy that our latest paper on NLRP3 activation is out, great work by Bali Lee @wellens_rose and everyone else!! science.org/doi/10.1126/sc…

Studying various cell lines, researchers probe the inflammasome #NLRP3 and show how disruptions to #endosomal trafficking can sensitize macrophages to NLRP3 activators, enhancing inflammasome activation and cytokine secretion. UoM Biology, Medicine and Health scim.ag/1En

Happy to share that our paper on the discovery of compounds that inhibit the AIM2 inflammasome is now published 🥳 – Check it out here cell.com/iscience/fullt…

⚠️ New #NF2 research paper out! I am elated! Are #NF2SWN #vestibularschwannoma similar or different to sporadic tumours? Read the paper or the video abstract to find out! academic.oup.com/braincomms/art… Thanks to our fab authors and funders NF2 BioSolutions UK & Europe NF2 BioSolutions Division of Neuroscience

An exciting PhD opportunity to join my lab studying NLRP3 inflammasome in vascular dementia. This project is in collaboration with KasherLab Prof. David Brough, and Dr. Ingo Schiessl. Please contact me for details ([email protected]) findaphd.com/phds/project/m…

My first ever research paper is out !! 👩🏼‍🔬🎉 👉👉pubmed.ncbi.nlm.nih.gov/38327788/ A natural product "brazilin" inhibits the NLRP3 inflammasome pathway, a key driver of numerous inflammatory human diseases including those affecting the brain such as stroke and dementia.

Our paper is now out in Cell Reports! Please give it a read, particularly those interested in #microglia, #macrophages, and #stroke. We show the MNP response to stroke is all about where you're from (ontogeny), where you're at (space), and where youre heading (substates).

Our new paper exploring the nuclear role of pro-IL-1α is out now in Nature Comms! nature.com/articles/s4146… A first for myself as a first author and Chris Hoyle as corresponding author… go team!! 💪🏻 Such valuable work and support from all the other wonderful people involved ✨

In some animals, a crucial protein has evolved to work differently, like a chef who no longer needs to be in the control room but still coordinates with the team for a more efficient kitchen. Chris Hoyle Rose Wellens nature.com/articles/s4146…

NEW PAPER ALERT! 🚨 And it dropped on my bday, so thanks @BrainComms! C9orf72 dipeptides activate the NLRP3 inflammasome 👇🏻👇🏻👇🏻 Huge thanks to Chris Hoyle, Jack Rivers-Auty, Catherine Lawrence & the rest of the team not on X, plus Alzheimer's Society For Researchers for funding. academic.oup.com/braincomms/art…

Have you submitted your abstract yet? Don't miss out on this great meeting! Fantastic line up (really!!) and great occasion for ECR to present their research for talks and poster!

New MRC DTP PhD project is available with David Brough, Kevin Couper, Roy Ng and myself looking at the NLRP3 inflammasome in the brain and brain disease findaphd.com/phds/project/m…. Please get in touch with Prof Brough to discuss if you are interested! BrainInflammationGrp