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Happy to share a new study from our multitalented fellow Eva Tsaousidou ⁦@gshlab_ulkerctr⁩ in collaboration with ⁦Chowdhury Lab⁩. Here, we show that tolerable activation of p53 protects against cancer at the cost of metabolic health 👏🧿. cell.com/cell-reports/f…

Happy to share a publication from the lab demonstrating that 53BP1 loss is a positive predictive biomarker for immune checkpoint blockade efficacy, with important implications for the treatment of PARPi-resistant ovarian and pancreatic cancers! nature.com/articles/s4146…

📢SAVE THE DATE: 7-10 July 2025 @AgnelSfeir , Karlene Cimprich & Chowdhury Lab are chairing the #BGFP25 which is taking place in wonderful Lisbon, Portugal next July.☀️ Registration is now OPEN, for more info and details on how to register, follow the 🔗: bit.ly/3AnsVZF

Very grateful that Dana-Farber’s Center for BRCA and Related Genes in collaboration with the UT Health San Antonio has been awarded a $3M program project grant from the National Cancer Institute. Honored to lead the research under the new grant with Dr. Panagiotis (Panos) Konstantinopoulos.

Happy to announce our new publication in Nature Communications, spearheaded by super-talented project leader M@x R. . We identified that helicase loading is a self-limiting reaction supporting equal distribution of the replicative helicase across the genome. rdcu.be/dRTAZ

Out in nature today! We report that a CDK5-cyclin B1 complex maintains proper cell division. We discovered that CDK5, a long regarded non-cell cycle CDK functioning only in neurons, yet overexpressed in many cancers, does regulate mitosis!  Link: nature.com/articles/s4158…

🚨 TENURE-TRACK Faculty Opportunity The Genome Integrity Program UMass Chan Medical School umassmed.edu/genomeintegrit… Join us exploring DNA replication/repair with Core services supporting your cutting-edge research. 🔗 Learn more: academicjobsonline.org/ajo/jobs/28037 #Genomics #FacultyJobs #Research #Science

📣 Excited to share our latest review on 53BP1’s function in replication stress, its role in fork protection, and the significance of 53BP1 nuclear bodies in this context! sciencedirect.com/science/articl…

Thank you to Chowdhury Lab (@Harvardmed, Dana-Farber) for joining us for a fantastic #WednedsayLectureSeries on "#DNA repair mechanisms in the context of cell cycle with implication in #cancer." 🧬 Hosted by the Si Lab.

Excited to share our publication out in Science today! We define a role for the CST complex in DSB repair pathway choice. This study was conducted in close collaboration with Patrick Sung’s lab. Congratulations to Michelle Swift and all other authors! science.org/doi/10.1126/sc…