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The evolutionary velocity paper ended on a cliffhanger: protein language models could predict evolution retrospectively, but could they also run evolution forward to prospectively design new proteins? So, I retrained as a protein biochemist to find out... biorxiv.org/content/10.110…

Excited to share our new ESM-IF1 inverse protein folding model. The result of scaling inverse folding with millions of predicted structures. Paper: biorxiv.org/content/10.110… Model: github.com/facebookresear…

This large scale inverse folding project wouldn't have been possible without Adam Lerer. Very grateful for the mentorship during the internship and the opportunity to work together. Also would love to see this gets used for designing new proteins.

Had fun putting together this review! Lots of good surveys of the literature lately so mostly we used it as a chance to look carefully at the key impacts on de novo design, and sneak a few hot/cold(?) takes. Also we figured out a way to reference elephants 🐘 in the text 😂

if you feel appalled by this and want to help advance the status quo of ML for single-cell data, let's talk