A Potential Target for Diabetes: (GSK-3) Glycogen Synthase Kinase-3? drugdiscoveryhub.com/a-potential-ta…

Latest total synthesis is on ChemRxiv - a truly comprehensive dearomatization strategy! Congratulations to Andreas zur Bonsen and thanks to Chris Sumby for the X-ray structures Bioinspired Total Synthesis of Hyperireflexolides A and B | ChemRxiv - go.shr.lc/3DbWbkc

Huge thanks to CSU Department of Chemistry for hosting #PfizerChemistry for a virtual outreach today and Andy McNally and Bandar Labs and everyone else for joining in (and listening to me go on for too long talking about GLP-1 agonists) doi.org/10.1021/acs.jm…

CNS drug: Ozanimod: In 2020, the FDA authorised ozanimod for the treatment of relapse multiple sclerosis, which includes active secondary progressive multiple sclerosis , clinically isolated syndrome, and relapsing-remitting multiple sclerosis.  drugdiscoveryhub.com/central-nervou…

New class of oral small molecule drug: Ritlecitinib. Ritlecitinib is used for treating severe alopecia areata, which causes hair loss on the scalp and other parts of the body. Litfulo was approved by the FDA in June 2023. drugdiscoveryhub.com/new-class-of-o…

23 PROTACs and 10 Molecular glues in the clinic! Am I missing anything? protein-degraders.com/clinic/

Sotagliflozin drug approved in May 2023 to treat Diabetes drugdiscoveryhub.com/sotagliflozin-…

The Most Significant Advancement in HIV Treatment : Cabotegravir drugdiscoveryhub.com/the-most-signi…

Endometriosis and Uterine Fibroids: Gynecological Diseases drugdiscoveryhub.com/endometriosis-…

The Latest Advancements in Small Molecule Drugs for Insomnia.#insomnia #Daridorexant #Lemborexant My Blog: drugdiscoveryhub.com/the-latest-adv…

Treatment of sickle cell disease (SCD): Osivelotor (GBT-601), a second-generation drug. #sicklecelldisease #Osivelotor #GBT601 My blog: drugdiscoveryhub.com/treatment-of-s…

Psoriatic disease: recent advances in small molecules. #psoriasis #Deucravacitinib For more information blog: drugdiscoveryhub.com/psoriatic-dise…

discovery of LUNA18 as an orally bioavailable cyclic peptide KRAS inhibitor(Chugai Pharmaceutical Co. Ltd.) pubs.acs.org/doi/abs/10.102…

Optimizing the drug-like properties should be your design focus for antibody-drug conjugates (ADC). Research from @AbbVie in #JMedChem Read the article here ➡ go.acs.org/5Bm

The first FDA-approved treatment for Demodex Blepharitis, a common eyelid disease caused by microscopic mites living in the eyelashes' hair follicles. #Lotilaner For more information blog: drugdiscoveryhub.com/lotilaner-firs…

PROTAC-mediated CDK degradation differentially impacts cancer cell cycles due to heterogeneity in kinase dependencies nature.com/articles/s4141…

📢Good news from Kemijski inštitut! Our partners have published an article (with Project ESTELLA in the acknowledgements) about lignin and covalent adaptable networks in ACS Sustainable Chemistry & Engineering 📄. 👉Click on the link to read the complete article: pubs.acs.org/doi/10.1021/ac…

Interested in how #molecularglues do the gluing but only have a few minutes to spare? ⏰ Have a look at a one-page digest of our recent manuscript, a new Nature Portfolio format: bit.ly/46bFgLj