Higher Molecular Injury at Diagnosis of Acute Cellular Rejection Increases the Risk of Lung Allograft Failure dlvr.it/T17CRn

Serum Cell-free DNA-based Detection of Mycobacterium Avium Complex Infection dlvr.it/T17CT9

Liquid Biopsy: An Evolving Paradigm for Non-invasive Disease Diagnosis and Monitoring in Medicine dlvr.it/T18JxF

Exploratory Biomarker Analysis Using Plasma Angiogenesis-Related Factors and Cell-Free DNA in the TRUSTY Study: A Randomized, Phase II/III Study of Trifluridine/Tipiracil Plus Bevacizumab as Second-Line Treatment for Metastatic Colorectal Cancer dlvr.it/T197Lf

Comprehensive Genomic Analysis of Patients With Non-Small-Cell Lung Cancer Using Blood-Based Circulating Tumor DNA Assay: Findings From the BFAST Database of a Single Center in Taiwan dlvr.it/T1BfvJ

The role of microRNAs involved in the disorder of blood-brain barrier in the pathogenesis of multiple sclerosis dlvr.it/T1Bfx7

Circulating free DNA and its potential in the diagnostics and therapy of malignant lymphoma dlvr.it/T1BfxL

Plasma cell-free DNA as a sensitive biomarker for multi-cancer detection and immunotherapy outcomes prediction dlvr.it/T1BfxR

Keeping a track on leptomeningeal disease in non-small cell lung cancer: A single-institution experience with CNSideTM dlvr.it/T1BfxX

Read our perspective on how to surpass sensitivity limits in liquid biopsy science.org/doi/abs/10.112…

Excited to present the first ageing clock based on nucleosomics of cell-free DNA (cfDNA)! onlinelibrary.wiley.com/doi/10.1111/ac… ✅ Nucleosome repeat length increases with age ✅ Can predict age with ~3 year precision Congrats to Mariya Shtumpf, nrnflowers, Mila Bikova, Hulkar_M, Lumi Ruje!

Read the latest from Enseqlopedia on my blog: enseqlopedia.com/2024/02/pushin… Priming agents to increase cfDNA levels for #liquidbiopsy by Broad Institute Massachusetts Institute of Technology (MIT) Keith Robison Albert Vilella Shawn Baker Manal Mehta this is some pretty #coolscience I know you'll be interested in.

Our paper on nucleosome repositioning in breast cancer is now published in Clinical Epigenetics! …lepigeneticsjournal.biomedcentral.com/articles/10.11… ▶️Nucleosome gain marks deregulated TFs ▶️Shorter distances between nucleosomes in cancer ▶️NRL affected by gene expression, methylation, H1 histones, repeats

Interesting news from GRAIL trial in the UK - accuracy in the article given as 56% One of the main issues I think with Galleri is its model trained on late stage disease, and is a “fixed” panel. We need broader WG assays trained on early disease hsj.co.uk/quality-and-pe…

Based on the ECLIPSE trial, U.S. FDA today approved the Guardant SHIELD blood test for #ColorectalCancer. Matthew Herper in STAT statnews.com/2024/07/29/gua… See ECLIPSE data below & why individuals undergoing this assay should clearly understand - this is NOT a test for CRC

We have an opening for a three-year postdoctoral position for a researcher with expertise in machine learning and genome bioinformatics, to work on cancer diagnostics (liquid biopsies). Please apply here: vacancies.essex.ac.uk/tlive_webrecru…

💡Will #ctDNA serve as a treatment response biomarker in metastatic cancers? Here’s a thorough evaluation in Clinical Cancer Research from the RECIST working group, looking at the next steps towards using ctDNA for novel early endpoints in clinical trials and beyond. 👉 doi.org/10.1158/1078-0…

Interesting preprint on nucleosome spacing from cfDNA [Johnston et al., 2024] biorxiv.org/content/10.110…. The authors refer to NRL changes 10n -> 10n-5 bp. Earlier we showed that NRL decrease in cancer is more complex & context-specific [Jacob et al., 2024] link.springer.com/article/10.118…

Very happy to contribute to this paper about cfDNA in SCLC, led by the team of Anish Thomas. It's already online in Genome Medicine: Takahashi et al., Genomic alterations and transcriptional phenotypes in circulating free DNA and matched metastatic tumor genomemedicine.biomedcentral.com/articles/10.11…

We have a postdoctoral opening for a researcher with experience in bioinformatics of DNA sequencing and machine learning to work on the development of new methods for cancer diagnostics related to nucleosomes, chromatin and more jobs.ac.uk/job/DMK060/sen…. Apply by 21st April 2025!