Mapping influenza across the ages: Bloom Lab examines how mutations to H3N2 #influenza HA affect neutralization by human sera across age groups, revealing variable effects by age. H3N2 esp acquires mutations escaping neutralization by sera of teenagers cell.com/cell-host-micr…

MADS, an anti-phage defense. Alice Maestri Anne Chevallereau @edzewestradescribe an innate immune system, MADS (methylation-associated defense system), that interacts with #CRISPR-Cas in its native host to provide strong & long-term protection against #phages cell.com/cell-host-micr…

Shared evolutionary roots for viral defense. Daan F van den Berg Ana Rita Costa & Esser Stan Brouns discover bacterial homologs of eukaryotic antiviral defenses and demonstrate the anti-phage activity for six previously uncharacterized systems cell.com/cell-host-micr…

Microbial metabolome in septic shock: Bridging bench to bedside Vandewalle &Libert IRC - VIB/UGent highlight Emily Balskus Cell approach addressing major sepsis hurdles-early recognition, treatment, translation from models to patients & therapeutics cell.com/cell-host-micr…

#Salmonella re-engineers the intestinal environment to break colonization resistance in the presence of a compositionally intact #microbiota. Cell Host & Microbe paper from Andreas Baumler UC Davis lab cell.com/cell-host-micr… #OpenAccess

Most studies on the gut microbiome and colorectal cancer show only associations. This new perspective in Cell Host & Microbe updates types of microbiome variability and the factors influencing these types of variability in the context of colorectal cancer: cell.com/cell-host-micr…

Personalized treatment plans, driven by diet and medication based on the patient’s microbiome and clinical markers, could optimize therapy for type 2 diabetes. This review in Cell Host & Microbe updates how disruption of gut homeostasis impacts diabetes: cell.com/cell-host-micr…

Respiratory viruses & pneumococcal carriage: Elena Mitsi Daniela Ferreira explored effects of respiratory viral infection on pneumococcal colonization & transmission in adults. Prior RSV or rhinovirus promoted pneumococcal acquisition upon challenge cell.com/cell-host-micr…

Salmonella breaks colonization resistance Salmonella overcomes colonization resistance w/intact microbiota by disrupting epithelial hypoxia. Outgrowth fueled by catabolizing simple sugars via combo of aerobic respiration & mixed acid fermentation Andreas Baumler cell.com/cell-host-micr…

Pleased to see our paper published in Cell Host & Microbe. We explored how certain respiratory viruses affect pneumococcal carriage acquisition, combining natural viral infection with experimentally induced pneumococcal carriage. cell.com/cell-host-micr…

Out in Cell Host & Microbe: Conservation of antiviral systems across domains of life reveals immune genes in humans. Using phylogenomics, we traced antiphage systems in eukaryotes, predicted human homologs and validated their immune function in human cells! cell.com/cell-host-micr…

August 2024 "Paper of the Month" Award 🏆: It's ours! The selection committee never pretended to be unbiased 😂. Check it out now Cell Host & Microbe ! cell.com/cell-host-micr… Kodi Ravichandran Lars Vereecke Mahesh Desai Lab Priscilla Chin

A study in Cell Host & Microbe concludes that "maternal antibiotic prophylaxis during cesarean section has a limited impact on the infant #gut #microbiome" Trishla Sinha A.Zhernakova Asier Fernández Alex Kurilshikov 👇 cell.com/cell-host-micr…

Clinical sequelae of gut microbiome development & disruption in preterm infants New work characterizes gut microbiome dynamics over first 3 mos in preterm hospitalized infants, revealing impacts of antibiotics & drugs & associations w/NEC GD cell.com/cell-host-micr…

Engineered probiotic ameliorates ulcerative colitis. Lactobacillus casei engineered to contain embedded selenium dots (Se-fLac) for restoration of intestinal redox & microbiota homeostasis. Se-fLac reduces inflammation & colonic damage in #colitis models cell.com/cell-host-micr…

Inter-kingdom communication controls recovery following chemotherapeutic injury Cell death fuels dysbiosis &disease post chemotherapy. Intestinal epithelial cell apoptosis & metabolites promote Enterobacteriaceae, delaying recovery Anderson lab @kodirav cell.com/cell-host-micr…

Conservation of antiviral systems across domains of life. MDMLab Aude Bernheim demonstrate that homology search of antiphage systems in eukaryotic genomes can be utilized to discover human immune proteins cell.com/cell-host-micr…

Determinants of heightened newborn vulnerability to norovirus diarrhea New work from Karst Lab_UF demonstrates in mice that neonatal metabolic immaturity and breastmilk bile acids underlie the newborn’s heightened vulnerability to norovirus disease cell.com/cell-host-micr…

B. ovatus alleviates dysbiotic microbiota-induced GVHD B. ovatus reduces severity of GVHD by suppressing mucus-degrading gut microbes. Beneficial effects linked to metabolism of dietary polysaccharides into monosaccharides Jenq & Hayase MD Anderson Cancer Center cell.com/cell-host-micr…

nBregs & early-life microbiota Newborn regulatory B cells (nBreg) autocrinally regulate IgM via IL-10. mAbs from intestinal nBregs react against diverse bacteria, highlighting role of nBreg Abs in microbial diversity & early-life microbiota communities cell.com/cell-host-micr…