Thrilled to introduce a new single-cell 3D genome analysis tool to our toolkit! Our high-throughput droplet Hi-C (dscHi-C) and dscHi-C-multiome methods use droplet microfluidics to generate tens of thousands of single-cell Hi-C profiles with high sensitivity in a single batch.

Generation of live mice from haploid ESCs with germline-DMR deletions or switch by Jinsong Li @ CEMCS, CAS, Wen Li Shanghai Jiao Tong University & co #imprinting nature.com/articles/s4142…

Droplet-based high-throughput 3D genome structure mapping of single cells with simultaneous transcriptomics by SunneyXie Honggui Wu Maoxu Wang & Yinghui Zheng Peking University nature.com/articles/s4142…

Generation of live mice from haploid ESCs with germline-DMR deletions or switch pubmed.ncbi.nlm.nih.gov/39833184/

In this new Cell Discovery study, researchers established a fusion system between androgenetic-haploid ESCs (haESCs) and parthenogenetic-haESC lines with parent-of-origin-specific-DMR edits to produce diploid #ESCs carrying DMR-deletion combinations. 🔗 go.nature.com/3CkOr2I

By combining pathological image analysis with spatial proteomics, scientists with Dr. Jia Fan revealed two stromal archetypes in #HCC with different biological functions and #ECM compositions. 👉 Read their Cell Discovery study: go.nature.com/3Cv2pz4

Scientists from Chinese Academy of Sciences generated functional HSPCs in vitro from #endothelial cells (ECs) at various sites, including the aorta-gonad-mesonephros region and the placenta, by engineering vascular niche ECs. 🖨️ Cell Discovery go.nature.com/3WEEGTI

Don't miss this new Cell Discovery release! 📣 Findings suggested that placental hemogenic endothelial cells possess the potential to transform into self-renewing induced #HSPCs through retinoic acid treatment. 🔎 Discover more: go.nature.com/3WEEGTI

Mettl3-m6A-NPY axis governing neuron–microglia interaction regulates sleep amount of mice by Xuekun Li, Qiang Shu, Daqing Ma, Jinpiao Zhu & co Zhejiang University nature.com/articles/s4142…

Conversion of placental hemogenic endothelial cells to hematopoietic stem and progenitor cells by Feng Liu @ IOZ, CAS, Jing-Dong Jackie Han Peking University & co #HSPC nature.com/articles/s4142…

Stromal architecture and fibroblast subpopulations with opposing effects on outcomes in #hepatocellular carcinoma by Jia Fan, Kui Wu, Yidi Sun, Hu Zhou, Qiang Gao & co nature.com/articles/s4142…

A tumor-secreted protein utilizes glucagon release to cause host wasting by Wei Song, Zhiyong Yang, Yufeng Yuan & co Wuhan University nature.com/articles/s4142…

NF-κB RelB suppresses the inflammatory gene expression programs of dendritic cells by competing with RelA for binding to target gene promoters by Alexander Hoffmann, Jennifer J. Chia & co UCLA nature.com/articles/s4142…

Human DDIT4L intron retention contributes to cognitive impairment and amyloid plaque formation by Xu Zhang, Ying Mao & co nature.com/articles/s4142…

Transgenerational inheritance of diabetes susceptibility in male offspring with maternal androgen exposure by Han Zhao, Zi-Jiang Chen, Yuqing Zhang 山东大学 SHANDONG UNIVERSITY & co nature.com/articles/s4142…

MAPK13 phosphorylates PHGDH and promotes its degradation via chaperone-mediated autophagy during liver injury by Weiwei Yang & co @ CEMCS, CAS nature.com/articles/s4142…

Historical loss weakens competitive behavior by remodeling ventral hippocampal dynamics by Ling-Qiang Zhu, Dan Liu, Kai Shu & co Huazhong University of Science and Technology nature.com/articles/s4142…

RNA cytidine acetyltransferase NAT10 maintains T cell pathogenicity in inflammatory bowel disease by Hua-Bing Li, Jing Zhou, Ping Wang & co Shanghai Jiao Tong University nature.com/articles/s4142…

#TMEM41B is an endoplasmic reticulum Ca2+ release channel maintaining naive T cell quiescence and responsiveness by Min Peng, Bingqing Xia, Zhaobing Gao & co nature.com/articles/s4142…

Structural basis for catalytic mechanism of human phosphatidylserine synthase 1 #PSS1 by Jingpeng Ge ShanghaiTech University, Jie Yu & co nature.com/articles/s4142…