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I'm really outraged by the French govt's decision to cut almost €1 billion from the research and higher education budget. We're already far behind Germany, Austria, Belg., USA, etc. (2.22 vs 3.14, 3.26, 3.43, 3.46, etc. Wd Bk data) in terms of % of GDP devoted to research & dvpt

Buckle up for your Sunday read on the bacterial integron. Recombination sites come in many different shapes and their recombination efficiencies differ by 5 orders of mag?? Great study now on bioRxiv doi.org/10.1101/2024.0… by Kate in collab with Loot Céline and Didier Mazel 1/4

The follow-up of our January Science advances paper! I am sure that you are all willing to know how survive the superintegron inversion? here it is , congrats Loot Céline Egill Richard journals.plos.org/plosgenetics/a…

It’s online! Follow up study from my main PhD project where we find how point mutation in the integrase and genomic rearrangements buffer the toxicity associated with cassette excision in the Superintegron in V. cholerae over just a few generations! journals.plos.org/plosgenetics/a…

onlinelibrary.wiley.com/doi/full/10.11… No more atypical, but still permissive! Kudos Kevin Debatisse Manuel, Philippe, Pascal and the rest of the Toulousains! even Antoine 𝗔𝗻𝘁𝗼𝗶𝗻𝗲 𝗗𝗨𝗣𝗢𝗡𝗧 😉

New preprint alert!🚀 Excited to share our latest preprint, where we discover a vast arsenal of phage anti-defense proteins using an interpretable machine-learning approach. Big thanks to Martin Polz, @ShaulPollak, Mariusz Ferenc, and all collaborators! biorxiv.org/content/10.110…

Sedentary chromosomal integrons (SCIs) are biobanks of anti-phage defence systems! In a huge collaboration with the Didier Mazel lab, we showed that these flexible genetic platforms encode known defences and further discovered 16 new systems. A thread (1/n) doi.org/10.1101/2024.0…

MDMLab Baptiste Darracq @epcrocha Loot Céline Didier Mazel @FredoLeRoux David Bikard Aude Bernheim weronika slesak Kevin Debatisse Finally, have also a look at a related study led by Nicolas Kieffer, PhD from Jose A Escudero's group, released back-to-back doi.org/10.1101/2024.0…

One of the cool advantages of working at Institut Pasteur, since 1887 is having great microbiologists around. Many 🤯discussions on the theme of anti-phage systems and MGE in the last years with @epcrocha David Bikard Didier Mazel labs. Awesome review cell.com/cell-host-micr… And now integrons 👇 !

Check out our latest preprint! This work was lead by Nicolas Kieffer, PhD with the support of the whole MBA lab, especially Alberto.HCA . If you are interested in the intersection between #Phage resistance and #AMR pull the thread! 🧵 biorxiv.org/content/10.110…

Let's not underestimate Integrons this time. They can bring cassettes from Chromosomal Integrons in many genomes. And you know what? These are packed with defence systems too!!! Check the back-to-back work from Didier Mazel Loot Céline Eloi Littner @epcrocha biorxiv.org/content/10.110…

15 years after doing my PhD on integrons with Didier Mazel, I'm thrilled to see my old and new interests united with the exciting discovery of anti-phage genes in these fascinating genetic recombination systems.

1/ 🧵 Thrilled to share work of Eligo Bioscience just published in nature ! We show proof of principle results of efficient base editing performed on E. coli directly in the mouse gut 🦠💡 #Microbiome #SyntheticBiology nature.com/articles/s4158…

Finally out after peer review. The first SuperIntegron-less Vibrio cholerae... and it is virtually identical to the WT! doi.org/10.1093/nar/gk…

Join us in Paris on April 8th-10th for the 2025 Symposium on the Immune System of Bacteria 🥖🍷🦠🧬. Excited to welcome these amazing speakers at Institut Pasteur, since 1887 . Registration will open beginning of November. Abstract deadline February 28. Stay tuned.

Our last contribution to the technology arsenal for Vibrio cholerae by Kevin Debatisse Loot Céline bmcgenomics.biomedcentral.com/articles/10.11…

Finally out after peer review, our update on the integron model showing that translation rates of cassettes in first position influence the phenotypes conferred by others downstream. Great effort by André Carvalho nature.com/articles/s4146…

Félicitations à nos lauréats du Prix Agnes Ullmann ! Zeynep Baharoglu explore l’impact des modifications de l’ARN sur la résistance aux antibiotiques. Thomas Rolland contribue dans le domaine la génomique des troubles neurodéveloppementaux. Bravo pour à eux pour ces travaux !

Exciting update on this study - stop by on the blue side to learn more about it...

White smoke, we have not only a new pope, but also 16 new anti-phage systems in integrons ! In collaboration with the Didier Mazel lab, we show in our new paper that cassettes of these large platforms encode known anti-phage defenses and uncovered 16 new ones. science.org/doi/10.1126/sc…