A new study from Mount Sinai reveals that human-derived monoclonal antibodies targeting the mpox A35 protein completely protected mice from severe disease and death—blocking viral spread in both lab and animal models. #MpoxResearch #InfectiousDiseases cell.com/cell/fulltext/…

Researchers have unveiled the first comprehensive roadmap detailing how the ovarian reserves forms in primates—revealing key cellular milestones, hormone surges after birth, and clues behind infertility and PCOS. #Infertility #OvarianReserve nature.com/articles/s4146…

New research reveals how cancers metastasizing to bone induce anemia: tumor cells hijack iron-recycling macrophages—essential for red blood cell production—to feed their own growth, starving the bone marrow and impairing erythropoiesis. #CancerResearch cell.com/cell/abstract/…

New preclinical findings spotlight ABHD18 as a promising therapeutic target for Barth syndrome. Inhibiting ABHD18 balances mitochondrial lipids and improves heart function in model, offering hope for this rare genetic disorder. #BarthSyndrome #Mitochondria nature.com/articles/s4158…

A newly developed ENPP1 inhibitor, STF-1623, boosts tumor residence of immune signals—turning “cold” tumors “hot” by preventing cancer cells from hiding from immune detection. A promising step towards better immunotherapies. #Immunotherapy #CancerResearch cell.com/cell-reports-m…

A new study shows a cocktail of non-neutralizing antibodies targeting influenza’s conserved M2e protein protects mice from multiple flu strains—including lethal ones—without viral escape. 💡🔬 #FluResearch #Antibodies #InfectiousDiseases science.org/doi/10.1126/sc…

CRISPR activation rescued SCN2A haploinsufficiency in mice—boosting gene expression from the healthy copy, reducing seizures, & improving neurological function even during adolescence. Big potential for treating SCN2A-linked disorders! #SCN2A #CRISPRa nature.com/articles/s4158…

Organoids recreating native kidney architecture now allow scientists to model complex kidney diseases in mice—opening new paths for research in disease mechanisms & drug discovery. #KidneyOrganoids #DiseaseModeling #TranslationalMedicine #Biotech cell.com/cell-stem-cell…

A new study reveals how longevity traits in C. elegans can be epigenetically inherited: lysosomal changes in parents trigger specific histone modifications that transmit lifespan benefits to offspring—without altering the DNA itself. #Epigenetics science.org/doi/10.1126/sc…

CRISPR screens have revealed genetic tweaks that boost CAR-T cell effectiveness against multiple myeloma. This insight could lead to stronger, more targeted immunotherapies. 🧬 #CRISPR #MultipleMyeloma #Immunotherapy #CancerResearch nature.com/articles/s4158…

Candida albicans fine-tunes the expression of its toxin, candidalysin—just enough to colonize the mouth without triggering immune alarm. This stealth strategy deepens our understanding of fungal persistence. #CandidaAlbicans #MicrobialEvasion nature.com/articles/s4156…

This innovative “GlyTR” approach targets tumor-associated glycans to trigger cancer cell death—without harming healthy tissue. A promising pan-cancer immunotherapy strategy. #CancerResearch #Immunotherapy #Glycans #Oncology #PrecisionMedicine cell.com/cell/fulltext/…

Researchers have isolated hundreds of new bacteriophages from the human gut and found that compounds from gut cells can awaken dormant viruses. #Virome #InfectiousDiseases nature.com/articles/s4158…

Scientists have discovered that planarian flatworm stem cells ignore their immediate neighbors and instead respond to distant signals (e.g. from intestinal cells). This challenges classic “niche” models & offers fresh insights for regenerative medicine. cell.com/cell-reports/f…

Exciting new findings: researchers discover that over-expression of the gene HMGN1 may underlie the congenital heart defects often seen in Down syndrome—offering fresh targets for therapy in Trisomy 21. 💡 #DownSyndrome #HeartDefects #HMGN1 #CRISPR nature.com/articles/s4158…

Fascinating discovery from the Dog Aging Project: post-translationally modified amino acids (ptmAAs) in dog blood show strong links to ageing, pointing to kidney function as a key mediator. Big step for aging biomarkers in pets & people. 🐕#CanineResearch onlinelibrary.wiley.com/doi/10.1111/ac…

New research from the Allen Institute shows age-related shifts in T cells drive weaker vaccine responses in older adults—especially a move toward a Th2-like state that limits B-cell antibody production. #Immunology #Vaccines #Aging #Tcells nature.com/articles/s4158…

Exciting news: Researchers used AI to design short peptides that reduce ribosome stalling in Escherichia coli—boosting protein yields for biomanufacturing of enzymes, diagnostics & biomaterials. #Bioprocessing #AI #SyntheticBiology #MicrobialTech pubs.rsc.org/en/content/art…

New research shows a specific subset of brain immune cells—microglia—can switch into a protective mode that slows Alzheimer’s disease–related plaque growth when the transcription factor SPI1/PU.1 is dialed down. #Alzheimers #NeuroImmunology #Microglia nature.com/articles/s4158…

Groundbreaking research reveals that targeting specific tumor-associated macrophages with dual antibodies (anti-DLL1 + anti-PD-L1) alongside tamoxifen can overcome endocrine resistance in ER⁺ breast cancer. #BreastCancer #Immunotherapy #Macrophages science.org/doi/10.1126/sc…