Identifying variant and genes associated with #Alzheimers is instrumental to understand the biology of AD and develop treatments. We have an open faculty position to work on large WGS dataset for early-onset, familial AD and endophenotype-based phenotypes: nature.com/naturecareers/…

Extremely excited to finally announce I'm starting my own lab on October 1st at the NeuroGenomics and Informatics Center center WashU Test Account Washington University Department of Neurology. Want to study Alzheimer, genetics, GWAS, X chromosome, multi-omics, and sex, APOE4, and ancestry effects? Join me! Ads in the thread.

We have a fully funded Postdoc position for #Alzheimer functional genomics, integrating #IPSC models and multi-omic approaches to identify causal and druggable pathways. More info cruchagalab.wustl.edu/positions/ WashU NeuroGenomics and Informatics Center

Great lab to do a postdoc or work as a scientist!!

Special thanks to our close collaborators Nir Barzilai Sofiya Milman 🎗️ at Albert Einstein College of Medicine - Official, Carlos Cruchaga lab at Knight ADRC, and Mormino Lab and Anthony Wagner at StanfordADRC. And Tobias Wüstefeld for the stunning Nature cover. 2/12

It was great to be part of this study by Hamilton Oh Jarod Rutledge, Ph.D. and Tony Wyss-Coray, where we contributed proteomics data from the Knight ADRC. Important findings that will help to understand aging processes

Check our latest paper: "Harmonization of CSF and imaging biomarkers in Alzheimer's disease", which is part of the ADSP Harmonization consortium. Harmonized CSF data for ADSP samples is already available at vmacdata.org/adsp-phc sciencedirect.com/science/articl…

We also found that COVID infection affected the levels and many AD relevant plasma proteins; sciencedirect.com/science/articl…

Multiple genes modify levels of sTREM2 and risk for #Alzheimer. In this study we integrated genetics and proteomics with functional genomics to identify novel genes implicated on disease pathogenesis Knight ADRC Washington University Department of Neurology SomaLogic …arneurodegeneration.biomedcentral.com/articles/10.11…

Interested in Single cell and Multiomics? Register for the NanoCourse! Offered by the experts Dennis Goldfarb, MollahLab, Tristan Qingyun Li, Guoyan Zhao. Learn genomics, proteomics, multiomics. Hands-on practice on data analysis and integration! @PapouinLab, neuroscienceresearch.wustl.edu/resources/nano…

Great lab, leveraging single cell and statistical transcriptomics to understand neurodegeneration!!!

Plasma proteomics identifies new biomarkers and predictive models for dystonia as well as specific dystonia presentations, and pinpoint to immune system, and reactive oxygen pathways to be implicated on disease. onlinelibrary.wiley.com/doi/10.1002/an… ANA Journals SomaLogic Washington University Department of Neurology

Getting ready to present some of our latest findings in using unbiased proteomics to identify novel hashtag#Alzheimer Biomarkers (lnkd.in/gP5p8Zdp) on the 12th Alzheimer's & Parkinson's Disease Drug Development Summit: alzheimers-parkinsons-summit.com

Molecular characterization of well phenotyped #Alzheimers cohorts will identify biomarkers and casual and druggable targets. In the Knight ADRC cohort we generated genetics, epigenetics, transcriptomics, proteomics and metabolomics in brain, CSF and blood. nature.com/articles/s4159…

We leverage human multi-omic data to identify causal and druggable targets and to create novel predictive models for #Alzheimers . Come to use the four talks and four posters at the #AAIC24. neurogenomics.wustl.edu/the-neurogenom…. Knight ADRC NeuroGenomics and Informatics Center Washington University Department of Neurology

Thomas Marsh, a @WUSTLdbbs student, just published his first manuscript looking the genetic architecture, predictive power and cross-tissue correlation of 11 #Alzheimers biomarkers and relevant proteins in CSF and plasma. #AAIC24 Knight ADRC alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…