Today in #journalclub we delved into the structure of the Flotillin complex. Fascinating insights into how this cage complex could induce membrane curvature and provide a sealed diffusion barrier, connecting membrane systems. biorxiv.org/content/10.110…

Great work from the McKenney lab reconstituting the KASH protein Nesprin-2 bridging actin to kinesin/MTs #journalclub biorxiv.org/content/10.110…

Today in #Journalclub we looked at how Alphafold2 models can guide prospective ligand discovery. A nice study combing in-silico docking and cryo-EM out now in Science Magazine science.org/doi/10.1126/sc…

In yesterday's #journalclub, we had a look at the interesting mechanism by which the UNC-104 motor (Kinesin-3 KIF1A homologue in C. elegans) is stabilised on Rab-3-containing synaptic vesicles - by Bhan and colleagues biorxiv.org/content/10.110…

Excited to share our latest study! We discovered that maintaining mammalian oocytes involves extraordinary protein longevity. These proteins support key functions like proteostasis, the cytoskeleton, and mitochondria. Our findings offer new insights into reproductive aging.

Very interesting work showing that local translation on axonal ER tubules is mediated by RRBP1 #JournalClub doi.org/10.1016/j.devc…

Great work from the Dodding and Woolfson labs showing how a designed peptide can activate kinesin in vitro and in cells #journalclub

Today in #journalclub, we discussed the fascinating molecular infrastructure of glutamatergic synapses biorxiv.org/content/10.110…

We're thrilled to share our new preprint: "Evolutionarily Conserved Principles of ESCRT-III-Mediated Membrane Remodeling Revealed by a Two-Subunit Asgard Archaeal System." biorxiv.org/content/10.110…

Today in Journal Club - Cross-link assisted spatial proteomics to map sub-organelle proteomes and membrane protein topologies nature.com/articles/s4146…

My first PhD student, Emma Hanford (nee Gleave), made some cysteine-lite dynein constructs in 2013. 11 years later, thanks to MinFlux, Joseph Slivka and Ahmet Yildiz they have been used in a nice biorxiv paper. doi.org/10.1101/2024.0…

Today at #journalclub we learned how bacteria protect themselves against phage infection by conjugating ubiquitin-like proteins to the phage tails 🤯 nature.com/articles/s4158….

Our paper looking at the structure of retrograde IFT trains is out now! Have a look at the link, or see some of the headlines in this video: cell.com/cell/fulltext/…

Would you like to work in the MRC-LMB EM facility? mrc.tal.net/vx/mobile-0/ap…

A fantastic paper describing a novel mechanism of selective inner mitochondrial membrane removal guided by lysosomal-mitochondrial communication (Dr. Akriti Prashar, Nicola Jones) #JournalClub nature.com/articles/s4158…

Today at #journalclub we looked at the structure of tubulin acetyletransferase bound to the microtubule lumen nature.com/articles/s4159…

A one day meeting on Friday 6th December covering all aspects (and scales) of Structural Biology.  Lots of talk slots to be selected from abstracts.  Deadline for abstracts is this Friday (15th Nov). bit.ly/4fDEqfZ

My PhD work is finally out in Journal of Cell Biology! 🎉 Reach out if you want to know more 😉

Check out this exciting new study led by Vanessa Teixeira revealing that CDR2 is a dynein adaptor and regulates ER sheet organization!!

Excited to share our latest work with the bullock lab! We looked at how diverse mRNAs get selected for subcellular localization and it turns out that a single protein can recognize different RNA elements using shared features that weren’t apparent before. biorxiv.org/content/10.110…