A new paradigm in intracellular #immunology: #Mitochondria emerging as leading #immune organelles 👇 sciencedirect.com/science/articl… Eric Topol

Replenishing the brain’s natural stores of lithium can protect against and even reverse Alzheimer’s disease go.nature.com/4mt8jSz

Hi everybody! I am super excited to share the work done during my PhD published in @nature today! We describe a new mechanism of self- vs. non-self RNA discrimination by showing how N-glycans shield glycoRNAs from stimulating endosomal RNA sensors nature.com/articles/s4158…

Another month, another insane protein design paper from the Baker Lab. This time: Designing binders for intrinsically disordered regions, a common & important component of proteins we care about, with the help of a diffusion model In nature last week

A new paper reports a proximity labeling-based method termed TAPRIP for profiling RNA-protein interactions in living cells, enabling the identification of circular RNA regulators and RNA G-quadruplex-specific binding proteins nature.com/articles/s4158…

🚨 All these players choosing Manchester United over others even without UCL football but because “We are Manchester United” was made possible by one man: Sir Alex Ferguson. 👑🫡❤️

Extroverta människor har svårt att sätta sig in i och förstå introverta. Själva får de en massa energi av att mingla, leka och gå på AW:n. De kan inte föreställa sig hur det känns när det sociala visserligen är trevligt, men dränerar en mentalt. Hela samhället idag är extrovert.

One use of RAPPL that I forgot to comment on is tandem purifications of nascent polypeptide chain or initiation factors if you are interested in protein folding, chaperons or translation initiation. More of this to come...initiation focus on attached image nature.com/articles/s4146…

In situ proximity labeling of proteins associated with circRNA and RNA G-quadruplexes: nature.com/articles/s4158…

Cryo-EM protein structure without purification biorxiv.org/content/10.110… #biorxiv_biochem

Rashy knows what he is talking about ❤️

Här är, gänget! Höga kustens lag. Från Kabben till idag.

Mitochondria protect against an intracellular pathogen by restricting access to folate | Science science.org/doi/10.1126/sc…

Nu snackar vi! Dags för säsongen att dra igång nu känner jag ❤️🤍💚

A genome is not a one-dimensional object. It is dynamic and quickly-changing, not only in TIME but also in SPACE. A new paper, published in Nature, reports the 3D structure of the E. coli genome. The whole thing was mapped with a resolution of 10 base pairs; enough to clearly

We noticed that Complex II assembly factor SDHAF2 accumulates in some OXPHOS deficient cell lines but not others (1/2) science.org/doi/10.1126/sc…

Two recent papers used deep learning to either create, or discover, new antibiotics. I'll first look at the paper that made new antibiotics from scratch (and then maybe write another post about the discovery paper.) The crazy thing about this paper, in particular, is that they

“The dose makes the poison.” It’s not just a slogan - it’s the foundation of toxicology. Let’s unpack why this simple idea destroys most of the fear-mongering around chemicals, pesticides, and food safety. 🧵👇1/

New online! Integrated structural biology of the native malarial translation machinery and its inhibition by an antimalarial drug bit.ly/4mluP07