The presence of inactivating mutations in RNF43, a negative regulator of WNT, in tumor cells predicts improved response rates & survival outcomes in patients with metastatic #BRAFV600E #ColorectalCancer treated with anti-BRAF/EGFR therapy. #NMEDclinical nature.com/articles/s4159…

BREAKING NEWS: The 2022 #NobelPrize in Physiology or Medicine has been awarded to Svante Pääbo “for his discoveries concerning the genomes of extinct hominins and human evolution.”

#ASCO24 | Investigadores del VHIO demuestran la utilidad de la biopsia líquida de alta sensibilidad para predecir y monitorizar la respuesta a inmunoterapia. Este estudio se enmarca en #CAIMI, financiado por Fundación BBVA y coliderado por Rodrigo Toledo y @ElenaGarralda, #UITM

🗞️ Published today at Cancer Discovery an international study led by ToledoLab_VHIO at #VHIO describes that oxygen-starved cancer cells develop similar survival strategies as the Sherpa population of the Himalayan region.  👉 linke.to/SherpaRToledoV…

"This study identified EPAS1, a gene critical for hypoxia adaptation in populations such as Tibetans and Sherpas, as playing a similar adaptive role in tumors arising under hypoxic conditions." 🤯🤯🤯 Cancer Discovery #Hypoxia aacrjournals.org/cancerdiscover…

🗞️ Publicado hoy en Cancer Discovery, un estudio liderado por ToledoLab_VHIO revela que algunos tumores comparten el mismo mecanismo de adaptación que los sherpas del Himalaya para sobrevivir en condiciones de falta de oxígeno.  👉 linke.to/SherpaRToledoV… Asociación PHEiPAS CIBERONC Fundación ”la Caixa”

Convergent Genetic Adaptation in Human Tumors Developed Under Systemic Hypoxia and in Populations Living at High Altitudes | Cancer Discovery | American Association for Cancer Research ⁦ToledoLab_VHIO⁩ ⁦Vall d’Hebron Institute of Oncology (VHIO)⁩ Amazing work Rodrigo & Carlota!! aacrjournals.org/cancerdiscover…

🗞️ Publicat avui a Cancer Discovery un estudi liderat per ToledoLab_VHIO Vall d’Hebron Institute of Oncology (VHIO) revela que alguns tumors comparteixen el mateix mecanisme d’adaptació que els xerpes de l’Himàlaia per sobreviure en condicions de manca d’oxigen. Llegeix la notícia 👉 vallhebron.social/JS0Wgg

#Oncología | 🏔️ Igual que los sherpas se adaptan al Everest, ciertos tumores también se 'aclimatan' a la falta de oxígeno. ➡️ Investigadores del Vall d’Hebron Institute of Oncology (VHIO) descubren que ambos activan el mismo gen: 'EPAS1'. 📄 Explican esta curiosa convergencia evolutiva en... diariomedico.com/medicina/oncol…

Now online in Cancer Discovery: Convergent Genetic Adaptation in Human Tumors Developed Under Systemic Hypoxia and in Populations Living at High Altitudes - by Carlota Arenillas, ToledoLab_VHIO, and colleagues doi.org/10.1158/2159-8… Vall d’Hebron Institute of Oncology (VHIO)

Big paper out today in Cancer Discovery! As ToledoLab_VHIO & Carlota say: from tumors to mountains🏔️-genetic convergence in low O₂ adaptation & cancer evolution reveals insights into cancer & potential targets. 💡acortar.link/WC6jWa Grateful to be part of this story!💫

Tumors que copien els xerpes tibetans per sobreviure amb poc oxigen: una de les últimes investigacions del Vall d'Hebron permet identificar gens clau per a la supervivència dels tumors. Això aplana el camí per fer noves teràpies 3cat.cat/324/alguns-tum… 3cat.cat/324/alguns-tum…

Vall d'Hebron Institute of Oncology (VHIO) - Oxygen-starved cancer cells develop similar survival strategies as the Sherpa population of the Himalayan region Vall d’Hebron Institute of Oncology (VHIO) Bruna Calsina oncodaily.com/url/271704 #VHIO #Sherpa #Cancer #OncoDaily #Oncology #GlobalAwareness

📢 Congratulations to our fresh newly elected #ENSAT ACC Working Group Head Barbara Altieri 👏 Looking forward to work with you! See our website for details regarding the Executive Committee and the Working Group boards ensat.org

The May issue of Cancer Discovery is now online! The cover features work by Carlota Arenillas, ToledoLab_VHIO, et al. providing evidence of convergent genetic adaptation in hypoxic tumors and in high-altitude populations. Read this and much more here: aacrjournals.org/cancerdiscover… Vall d’Hebron Institute of Oncology (VHIO)

📢Excited to share that our study is featured on the cover of the May issue of Cancer Discovery and selected for the "In the Spotlight" editorial.🙏Thanks to the collaborators,European Network for the Study of Adrenal Tumours CIBERONC Asociación PHEiPAS #ParadifferenceFoundation Pheo Para Alliance Fundación Fero Vall d’Hebron Institute of Oncology (VHIO) doi.org/10.1158/2159-8…

Featured on the cover: Convergent Genetic Adaptation in Human Tumors Developed Under Systemic Hypoxia and in Populations Living at High Altitudes brnw.ch/21wSxEo By Carlota Arenillas, ToledoLab_VHIO, and colleagues Vall d’Hebron Institute of Oncology (VHIO)

In the Spotlight: Under (Genetic Selection) Pressure: Human Tumors and Human Populations in Hypoxia brnw.ch/21wSE0o By Frank S. Lee at Penn

FDA approves belzutifan for pheochromocytoma or paraganglioma | FDA ⁦Asociación PHEiPAS⁩ ⁦NET- ESPAÑA⁩ ⁦Grupo GETNE⁩ fda.gov/drugs/resource…