📣VCF v4.5 is now live! The latest version supports: - Base modification calling - Improved scalability for large-cohort VCFs through local allele encoding and per-sample reference block definitions Visit the spec: bit.ly/3SDiyHy

So maybe I'm missing something but what's the actual X-drop condition in BlockAligner? I'm trying it out and it's aligning across indel with a penalty significantly larger that the X-drop threshold. Indel < max block size and X-drop only stops after eval to max? Daniel Liu

A free online course aims to bust COVID misinformation and teach people how to stop the virus spreading in schools. But perhaps its greatest challenge is engaging people in the first place — particularly those who believe COVID is harmless.ab.co/3MUMgnZ

Release 1.22.1 of HTSlib and SAMtools is now available from GitHub. This fixes crashes that could happen when reading malformed CRAM files, or when writing files with very long secondary alignments as CRAM 3.1. See htslib.org/download/ for links to tarballs and release notes

1/n The science doesn’t support these statements: 1) There are real environmental exposures that interact with autism genes, like valproate but not Tylenol. 2 The MMR vaccine is one of the safest most effective vaccines we have, breaking it up into components makes no sense…