1. Excited to share our new paper in nature! With over 1000 tumors analyzed by scRNA-seq, we provide a systematic pan-cancer characterization of transcriptional intra-tumor heterogeneity (ITH) nature.com/articles/s4158…

Illumina CEO Francis deSouza resigns after battle with Icahn reut.rs/3NoZXNi

RIP Bram Moolenaar en.wikipedia.org/wiki/Bram_Mool…

Using a deep generative model, CellBender models and denoises droplet-based single-cell data and improves multiple downstream analyses. Broad Institute Patrick Ellinor GATK Dev Team nature.com/articles/s4159…

From Jan 1, 2000, to Oct 31, 2022, FDA granted 573 oncology indication approvals for 206 distinct oncology products. Read more from a review by FDA authors: Trends in the approval of cancer therapies by the FDA in the twenty-first century. nature.com/articles/s4157…

I am hiring a #Postdoc in #singlecell #omics #cellandgenetherapy AstraZeneca linkedin.com/posts/kerry-sm…

Exciting postdoctoral position at Earlham Institute as part of a BBSRC research program to work in my group in close collaboration with EI Single Cell now @whatchamacaulay.bsky.social on the application of long read sequencing to study single cell heterogeneity earlham.ac.uk/vacancy/postdo…

In a world first, the UK medicines regulator has approved a therapy that uses CRISPR gene editing as a treatment for diseases go.nature.com/3QDtwuV

Everything you ever wanted to know about the @Illumina DRAGEN analysis workflow. Looks like a great prepub. 56 pages! "Comprehensive and accurate genome analysis at scale using DRAGEN accelerated algorithms" biorxiv.org/content/10.110…

Looking forward to speaking at the Festival of Genomics this afternoon about single cell omics data & analytics on behalf of AstraZeneca colleagues #FOG24

I am starting a new company:

The human chromosomes are numbered incorrectly (The fourth in an irregular series of threads about #Bioinformatics.) As most people know, 22 of our chromosomes are numbered from longest to shortest, plus we have X and Y... 1/6

What if we could universally recombine, insert, delete, or invert any two pieces of DNA? In back-to-back nature papers, we report the discovery of bridge RNAs and 3 atomic structures of the first natural RNA-guided recombinase - a new mechanism for programmable genome design

Direct to consumer polygenic score for shoe size

Impressive study showing that inhibiting interleukin-11, a pro-inflammatory cytokine, extends lifespan in mice by 25%. Both genetic deletion and an anti-IL-11 drug worked, and it's exciting that anti-IL-11 therapies are already in human clinical trials. nature.com/articles/s4158…

Excited to share our work on alternative splicing (AS) rdcu.be/dSHtu. This version, compared to the biorXiv one, is much more succinct due to word limits; I hope you will have a look. Congrats to @BenjaminFair3 and Carlos Buen Abad for their incredible work!🧵⬇️

Exciting advancements in healthcare! The new Clinical Transformer model enhances predictive analytics, potentially transforming patient care with improved outcome predictions. #HealthcareTech #AI #PredictiveAnalytics Read More: bit.ly/3YcDRmB

Exciting 4 years PhD position in my group to study alternative splicing regulation at Earlham Institute on the NRPDTP #LRUA24 earlham.ac.uk/studentship/me…

Our #DRAGEN methods paper in Nature is out. Proud of team Illumina and the collaboration with Fritz Sedlazeck BCM HGSC! Learn about the accuracy, scalability, the multi-genome mapping, machine learning, callers for genes in difficult to map regions. nature.com/articles/s4158…

Trying this