A breakthrough from the lab! A game-changer and the dawn of a new era in membrane and organelle biophysics and biology. We've generated giant organelle vesicles #GOVs with conserved biochemical activity. ANR - Agence nationale de la recherche @LP_ENS_ École normale supérieure | PSL Nature Communications nature.com/articles/s4146… 1/6

We are proud and excited to share the new study from our lab, led by the amazing Ranen Aviner. It uncovers an important pathogenic mechanism causing cellular dysfunction in Huntington's Disease. We hope this work will inspire new and effective therapies nature.com/articles/s4155…

Two weeks left to register for the 8th EMBO/FEBS lecture course on “Mitochondria in life, death and disease” (16-20 September). Amazing line-up of speakers and many possibilities for early career scientists to discuss science and career paths. #EMBOmitochondria #mito

Finally out! Unsaturated lipids regulate the growth of the apoptotic pore 🍩 Shashank Dadsena CECAD Cologne link.springer.com/10.1038/s41467…

Great to see our preprint out. We uncovered a simple likely mechanism to fuse inner+outer nuclear envelopes to precede nuclear pore complex (NPC) insertion. Our first step was to show that CLCC1 is the long-lost human homologue of Brl1 (previously only known in yeast, protists)

#MembraneContactSite community: Do not miss July 23, the earlybird registration deadline for our “Membrane Contact Sites in Cellular Homeostasis” Biochemical Society meeting in Edinburgh. Submit an abstract by then for being considered for a short talk! bit.ly/Membrane24

Very excited to participate in this "Membrane Contact Sites in Cellular Homeostasis" meeting in Edinburgh. Earlybird registration and abstract submission closes the 23rd of July. Don't miss it! bit.ly/Membrane24

Posor & Haucke discuss the recent study by jason casler, @LLLackner et al. Lackner Lab (hubs.ly/Q02JyKd30) describing how tripartite membrane contacts btwn #mitochondria, ER & plasma membrane regulate mitochondrial division & PI(4)P metabolism. hubs.ly/Q02JyTBm0

🥂Thrilled to see my latest #postdoc work out! What began as a quick, fun side project just before the first lockdown led me down a rabbit hole and ended in Nature Cell Biology 4.5y later: nature.com/articles/s4155… #autophagy #polyamines #fasting #caloricrestriction🧵1/11

Our new paper: Misfolded proteins activate HSF1 by releasing it from Hsp70. This has been clear in yeast for some time and we find that the mechanism is similar in human cells. sciencedirect.com/science/articl…

Wilson, Adam Hughes et al. observe that mitochondrial-derived compartments selectively incorporate proteins from only the outer mitochondrial membrane (OMM) and robustly sequester both excess and mistargeted proteins into this OMM-enriched domain. hubs.la/Q02L7pSP0

An exciting story from the lab! The balance of ceramide-glycerolipid synthesis in the ER regulates Caveolin1 localization. This is dependent on seipin, organizing #lipiddroplet formation. #Golgi #Caveolin1 #ER_literature #Diatetes #Metabolicdisorders biorxiv.org/content/10.110…

In a special seminar on Monday, October 07, at 12:00, @sfb1348.bsky.social will host Sabrina Büttner BüttnerLab, who just joined Universität Münster. Welcome to our scientific community! Don't miss Sabrina's seminar on  Organelle connectivity during cellular aging and metabolic adaptation!

Image summarizes the observations by Smith, Gay, and Babst University of Utah School of Biological Sciences proposing a new function for the tricalbins: mediating the fusion of the ER to the plasma membrane at contact sites. hubs.la/Q02QBxc40 #Membrane #lipid #Trafficking #Biochemistry #ER_literature

So happy to finally see this out! Great work by first authors Alexander Stockhammer and Petia Adarska which have shown that cargo flow along post-Golgi routes is driven by a key maturation step where compartments defined by ARF1 nature into recycling endosomes nature.com/articles/s4155…

TDP43 aggregation at ER-exit sites impairs ER-to-Golgi transport nature.com/articles/s4146…

Evolutionary origins of the lysosome-related organelle sorting machinery reveal ancient homology in post-endosome trafficking pathways | PNAS pnas.org/doi/10.1073/pn…

Join us for the DGZ Focus Workshop “Membrane Organization and Contact Sites” on Tuesday, March 25, 2025. Zoom-ID and passcode available in the flyer. Don't miss it!