Happy to share our recent work, led by Ethan Hollingsworth in which we discovered that poised chromatin sensitizes enhancers to aberrant activation by non-coding mutations, contributing to disease. UCI Charlie Dunlop School of Biological Sciences UC Irvine biorxiv.org/content/10.110…

An Amazing Journey From VEGF to HIF-2 Targeting Drugs KidneyCancerProgram KaelinLab UTSW Simmons Cancer Center guoncologynow.com/post/from-vegf…

A study co-led by Ben Sabari found that a gene fusion drives rare kidney cancer (tRCC) by forming protein clusters that disrupt gene activity. This may also occur in other cancers, revealing a potential new target for future therapies. #KidneyCancer #utsw bit.ly/3TSNOlW

Another terrific discovery by Ben Sabari and the Kidney Cancer Program under the leadership of James Brugarolas !

Our preprint describing the Range Extender element, which is required and sufficient for long-range enhancer activation at the Shh locus, is out in nature. nature.com/articles/s4158…

Our scientists have developed a tool called PHOTON that can map, at subcellular resolution, where RNA molecules are located in cells. See how this finding could eventually help researchers develop new treatments for neurodegenerative diseases. bit.ly/4nfCtKe #utswmed

Online Now: Reconciling competing models on the roles of condensates and soluble complexes in transcription factor function dlvr.it/TLjNk8

More than 2700 3′UTRs are highly conserved. These 3′UTRs are essential components in mRNA templates, as their deletion decreases protein activity without changing protein abundance. Highly conserved 3′UTRs help the folding of proteins with long IDRs. biorxiv.org/content/10.110…

Nucleosome spacing can fine-tune higher-order chromatin assembly: nature.com/articles/s4146…

Congrats to Huabin Zhou, Ph.D., a postdoc in the Rosen Lab, on receiving the 2025 Brown-Goldstein Award! His research on biomolecular condensates and chromatin structure is advancing our understanding of genome organization. Learn more: bit.ly/4lGmxzm

Principal Investigator Benjamin R. Sabari (Ben Sabari) along with other researchers at UT Southwestern Medical Center uncovers a genetic mutation that fuses two genes drives several different cancer types by forming networks of protein interactions that alter gene expression in cells.

Regulation of inflammatory responses by pH-dependent transcriptional condensates: Cell cell.com/cell/fulltext/…

Beyond excited to share our #NewPaper in Cell! Inflamed environments acidify intracellular pH. BRD4 senses this via transcriptional condensates, tuning #macrophage responses to match demand and consequences of inflammation. #inflammation #pH authors.elsevier.com/sd/article/S00…

Excited to share my first postdoc paper in Cell! We found that BRD4 transcriptional condensates act as a pH-sensitive “switch” to fine-tune inflammation. Huge thanks to my amazing mentors & collaborators!@XuZhouLab Ruslan Medzhitov Jonathan Kagan Ivan Zanoni

How do chromatin remodelers use #IDRs to find their TF binding partners? Check out San’s tweetorial about SWI/SNF (cBAF) subunit ARID1A and β-catenin, now online at Mol Cell

Excited to announce our paper describing how allelic variants in ribosome biogenesis factors cause neurodevelopmental disorders. Congratulations to co-first authors Chunyang Ni and Yudong Wei, our collaborator Jun Wu Lab and all the other authors. nature.com/articles/s4155…

The passing Of Dave Mangelsdorf is a terrible loss for his family, friends and the science world. Davo will never be forgotten. 😢 chapelgazette.cfd/david-mangelsd…

(1/n) Excited to share our new preprint! We uncover that RNA actively promotes nucleation and function of pathogenic condensates, amplifying locus-specific oncogenic transcription and promoting tumorigenesis. #epigenetics #condensates #cancer #RNA biorxiv.org/content/10.110…

We’re deeply saddened by the passing of David “Davo” Mangelsdorf, Ph.D., Professor and Chair of Pharmacology at UTSW, whose work on orphan nuclear receptors transformed our understanding of metabolism and endocrinology and inspired countless scientists. bit.ly/47jN4hK

#ResearchHighlight 🚨 Ben Sabari Ben Sabari &Co identified a common molecular signature in oncogenic fusion proteins that compartmentalizes RNA polymerase II to confer an increase in gene activation and consequent cancer phenotypes. 📖⬇️ bit.ly/3UtuoEM