Delighted to share our story out in Cancer Cell! Incredible amount of work led by Julia Belk and Winnie Yao, and wonderful collaborations with many close colleagues Santosh Vardhana Julia Carnevale @MarsonLab @MackallLab cell.com/cancer-cell/fu…

A new genetically-engineered mouse model (GEMM) enables purification of pMHCs from cells of interest, allowing for specific evaluation of the immunopeptidome of #cancer cells in vivo Koch Institute at MIT Alex Jaeger Read our summary here => ow.ly/OmUk50JKvjz

Co-authored tweets are now a thing but make no mistake: I will only allow co-authors from those who made significant intellectual contribution to the tweet. Also research techs and undergrads cannot make the author list, but will be included in the Acknowledgments section

Happy to share our latest work now out in @nature. At long last, we resolved the structure of the SHOC2-RAS-PP1C complex and integrated this work with deep mutational scanning to comprehensively evaluate #SHOC2 structure and function. 🧵(1/n) nature.com/articles/s4158…

"Thank you for volunteering to serve on this committee"

Presenting Slide-TCR-seq: our method for measuring the transcriptomes of cells & T cell receptor (TCR) sequences in situ! This collaboration w/ Bryan Iorgulescu, Shuqiang Li, Catherine Wu, and Fei Chen Lab led to some cool findings... cell.com/immunity/fullt… 1/8

Hagel et al. performed a genome-wide analysis that uncovered multiple mechanisms of CAR T-cell evasion by pancreatic cancer, paving the way for overcoming resistance. bit.ly/3J4SGjp Harvard Medical School

wondering what's the next big thing after spatial transcriptomics? 3D printed tube holders Fei Chen Lab

Every biology undergraduate degree in the United States has been obsolete for 30 years, serves its students poorly by failing to prepare them for the realities of the job market, and should be completely overhauled. Bring it on

Proud of Pratyusha Bala, @JonRennhack, Daulet Aitymbayev for this exciting scRNA-seq study on #ColorectalCancer initiation. science.org/doi/10.1126/sc… Matt Yurgelun, MD #ColorectalCancerAwarenessMonth

Introducing Slide-tags: our new technology for truly single-cell, multi-modal spatial genomics! Had a blast working alongside Andy Russell, Naeem Nadaf, Evan Macosko, Fei Chen Lab, and the rest of our team on this project! biorxiv.org/content/10.110… 1/9

(1/10) 🧵 Our recent study - and my MD PHD Thesis - finally got published in Nature Communications!!! We introduce SPTCR-seq, a method for detailed mapping of T cell receptors in glioblastoma. #CancerResearch #Immunology nature.com/articles/s4146…

Exciting new work from our lab describing a novel platform for MHC-II recognition, called TRACeR, that uses just a single loop! Congratulation to Haotian Du, Jingjia Liu, and the team biorxiv.org/content/10.110…

Today we report in Nature Communications the development of laboratory-evolved CBE6 cytosine base editors that offer high on-target C•G-to-T•A editing, virtually no A•T-to-G•C editing, low off-target editing, broad sequence context compatibility, and compatibility with multiple Cas

I love Austin, Texas.

Woolly mice is bioweapon.

In a medical milestone, a customized base editor was developed, characterized in human and mouse cells, tested in mice, studied for safety in non-human primates, cleared by U.S. FDA for clinical trial use, manufactured as a complex with an LNP, and dosed into a baby with a severe,

A baby named KJ, who was born with a rare genetic disorder – CPS1 deficiency – is healed thanks to doctors at the Children's Hospital who administered the world’s first personalized gene-editing treatment. The research team used base editing, a gene-editing method invented by HHMI