This year, our Medical Scientist (M.D./Ph.D.) Training Program (MSTP) is celebrating 50 years of training physician-scientists who strive to bridge two worlds, the clinic and the lab. 🩺🔬 Read ➡️ go.ucsd.edu/4n80Nhl

Top 5 advances in medicine this week (🧵) 1. Improving leukemia treatment Chronic lymphocytic leukemia (CLL) is a B cell cancer partially driven by a tyrosine kinase, BTK, and an anti-apoptotic protein, BCL-2 This phase 3 trial tests a combination of a BTK inhibitor

1/14 On behalf of the amazing team in Jonathan Weissman's Lab, we’re excited to share PEtracer (biorxiv.org/content/10.110…) a prime editing-based evolving lineage recorder compatible with both scRNA-seq and high-resolution imaging readouts in intact tissue. By applying PEtracer in a syngeneic mouse

Enhancers, how do they work (in vivo)? To find out, we mutagenized 7 human enhancers comprehensively in 12bp blocks and scored for activity in developing mouse embryos. rdcu.be/erD22 nature #mutagenesis #noncoding #enhancers

Our newest paper studying immunosuppressive astrocyte-GBM interactions using RABID-seq is out in nature today! Congrats to Brian Andersen and Camilo! nature.com/articles/s4158…

Introducing Epi-PHR, the first non-disruptive, high-genomic-resolution, image-based epigenetic profiling method. Allelic Epi-PHR generates the first single-cell phased examination of histone mark deposition and 3D genome architecture at an imprinted locus by any technique. 1/8

What I didn't expect to read today: Viagra (Sildenafil) can boost the immune response against cancer Viagra helps natural killer cells migrate to lymph nodes – from tumours – where where they meet and activate T cells

Excited to share our new preprint: "Cell-Free DNA Sequencing Uncovers the Longitudinal Consequences of Temozolomide Treatment and Host Co-Culture in Glioblastoma"! doi.org/10.1101/2025.0…

Which of these images is not like the other and why does it matter for cancer research? That fourth transform is what real tissues need but most spatial methods can't handle. Enter SAME, our algorithm for integrating multimodal spatial omics across near-serial sections.

This was a labor of love requiring lots of teamwork over years, repeating in 3 locations! Thanks to all the lab over the years, giving their time generously to this team project, & our wonderful collaborators. The source of fat matters for anti-tumor immunity 🐄🐖🧈🌴🫒🥥

Congrats to project scientist Raghav Vadla on his paper showing BRD2 bromodomain-mediated regulation of cell state plasticity. tinyurl.com/Vadla-et-al An exciting new direction to modulate therapy response in GBM! SNO NIHBrainTumor UCSD Division of Regenerative Medicine

Grateful to Meg Tirrell and CNN for covering this story. My NIH grant to study hearing loss was abruptly canceled, then restored by a court, but NIH hopes to terminate the grant AGAIN(statnews.com/2025/07/06/hhs…), creating massive uncertainty for my trainees. We're in a golden age

Excited to share our new work from Rosalind Xu, where we used MERFISH to build a single-cell spatial transcriptomic atlas of the mouse gut—and to explore host-microbiome interactions in situ! biorxiv.org/content/10.110… 1/

Thrilled to share our new paper describing the development and characterization of CDK11 inhibitors for cancer therapy. We also establish a new system that I think represents a huge leap forward in our ability to understand drug toxicity in a living organism.

Whole-genome single-cell multimodal history tracing to reveal cell identity transition biorxiv.org/content/10.110… #biorxiv_genomic

We are thrilled to have our spatial single-cell atlas of the Arabidopsis lifecycle in Nature Plants. It turns out that it is easy to generate aesthetic images when the spatial expression of 1,000 genes is available! 1/n Natanella Illouz-Eliaz 🎗️ Tatsuya Nobori Joe Ecker nature.com/articles/s4147…

Glad to share our latest publication in Nature Genetics Nature Genetics: Tracing the evolution of single-cell 3D genomes in Kras-driven cancers. In this work, we generated the first single-cell 3D genome atlases of any cancer using any technique.

Online Now: Long-range cholinergic input promotes glioblastoma progression dlvr.it/TMZVrT

Just published in nature, Clements et al. reveal that axonal injury is a key driver of early GBM progression, overturning the assumption that early GBM growth is purely tumor-cell intrinsic and showing neurons profoundly shape GBM biology throughout their life cyle

Extrachromosomal DNA biogenesis is dependent on DNA looping and religation by YY1-Lig3-PARylation complex dlvr.it/TMcnHP